Cell clusters softening triggers collective cell migration in vivo

Marchant et al. demonstrate in Nature Materials cells within clusters from embryonic tissue dynamically decrease their stiffness in response to temporal stiffening of the native substrate initiating collective cell migration.

They further show decreasing microtubule acetylation and consequent cluster stiffness is sufficient to trigger collective cell migration in soft non-permissive substrates.

Xenbase joins the Alliance of Genome Resources

A big leap forward for Alliance of Genome Resources (AGR) with the inclusion of Xenopus data from Xenbase

Check out the AGR...

19th International Xenopus Conference

Save the date!

Cambridge, Maryland USA

August 20-24, 2023

19thXenopusconference.org

Details on registration, travel awards for graduate students and postdocs, and meeting program coming soon.

#FrogFest23

Normal Table of Xenopus development: a new graphical resource

Zahn et al. published in Develoment a new normal table resource of images chronicling the development of Xenopus frogs.

View the Zahn drawings and landmarks table on Xenbase.

View the accompanying poster.

Cell landscape of larval and adult Xenopus laevis at single-cell resolution

Liao et al. published in Nature Communications their construction of the first Xenopus cell landscape to date, including larval and adult organs. They identify common cell lineage-specific transcription factors in vertebrates, including fish, amphibians and mammals. They provide a large-scale resource for research on Xenopus metamorphosis and adult organs.

Nascent transcriptome reveals orchestration of zygotic genome activation in early embryogenesis

Nascent transcriptome profiling during zygotic genome activation (ZGA) from whole Xenopus blastula and dissected subregions, Chen and Good (in Current Biology) unveil predominant transcription from maternal-zygotic genes and distinct spatial patterns, reconcile regulatory mechanisms of ZGA, and discover a link to sequential activation of germ-layer-specific genes.

Structure of the cytoplasmic ring of the Xenopus laevis nuclear pore complex

Zhu et al. published in Science the single-particle cryo–electron microscopy reconstruction of the cytoplasmic ring subunit from the Xenopus laevis nuclear pore complex at 3.7- to 4.7-angstrom resolution.

Focal Impact Model of Traumatic Brain Injury in Xenopus

Spruiell Eldridge et al. published in the International Journal Of Molecular Sciences modeling traumatic brain injury using Xenopus tadpoles.

Oocytes maintain ROS-free mitochondrial metabolism by suppressing complex I

Rodríguez-Nuevo et al. publish in Nature their study on oocytes maintaining cellular fitness. Combining live-cell imaging and proteomics in human and Xenopus oocytes, they find that early oocytes exhibit greatly reduced levels of complex I.

Vertebrate Cranial Placodes

Dr. Gerhard Schlosser published a two-volume book set through CRC Press detailing the development and evolution of vertebrate cranial placodes.

Phenotypes on Xenbase

The latest release of Xenbase includes the ability to search for Phenotypes.

Click here to go to the Phenotype search page.

Click here to find details on executing a Phenotype search.

Click here to find details on the Xenopus Phenotype Ontology (XPO).

Xenopus laevis v10.1 and Xenopus tropicalis v10 genomes

- both genomes fully integrated into Xenbase

- BLAST mRNA, protein, and CDS

- viewable on JBrowse

- morpholino tracks aligned

- relevant files available on Xenbase FTP and downloads page

Cell clusters softening triggers collective cell migration in vivo

Marchant et al. demonstrate in Nature Materials cells within clusters from embryonic tissue dynamically decrease their stiffness in response to temporal stiffening of the native substrate initiating collective cell migration.

They further show decreasing microtubule acetylation and consequent cluster stiffness is sufficient to trigger collective cell migration in soft non-permissive substrates.