Xenbase Image ID: 198952

Figure 5—figure supplement 1 Spatial expression of npr1, npr2, nppa and nppc by whole-mount ISH. Spatial expression of npr1, npr2, nppa, and nppc by whole-mount ISH at neurula (NF stage 15/16) and tailbud (NF stage 28/32) stages. The embryonic stages are indicated in the lower right corner of each panel. npr1 is broadly expressed at the neurula stage, and becomes enriched dorsally and anteriorly at the tailbud stage. In the head region it is detected in the branchial arches (white arrowheads). At neurula stage, npr2 is detected in the trigeminal placode (black arrowhead) and Rohon-Beard neurons (white arrowhead). Later in development, npr2 is detected in the trigeminal/profundal ganglion complex (black arrowhead) and in the branchial arches (white arrowheads). nppa appears to be diffusely expressed at neurula stage, and at tailbud stage nppa is exclusively restricted to the developing heart (black arrowhead) and otic vesicle (yellow arrowhead). At neurula stage, nppc is enriched at the neural plate border (black arrowheads), and at tailbud stage it is enriched in the prospective epibranchial placodes (white arrowheads) and otic vesicle (yellow arrowhead). Left column, dorsal views anterior to top. Right column, lateral views, anterior to right dorsal to top. Image published in: Devotta A et al. (2023) Copyright © 2023. Image reproduced with permission of the Publisher. Larger Image Printer Friendly View

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