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XB-PHENO-24158

Xtr Wt + rb1 CRISPR + rbl1 CRISPR + tp53 CRISPR + pten CRISPR, Naert T et al. (2020)

Experiment + Assay: Xtr Wt + rb1 CRISPR + rbl1 CRISPR + tp53 CRISPR + pten CRISPR + NF57-58 (histology)
Background: Xtr.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
CRISPR rb1 rb1
 NF stage 4 (8-cell) dorsal animal hemisphere blastomere
CRISPR rbl1 rbl1
 NF stage 4 (8-cell) dorsal animal hemisphere blastomere
CRISPR tp53 tp53
 NF stage 4 (8-cell) dorsal animal hemisphere blastomere
CRISPR pten pten
 NF stage 4 (8-cell) dorsal animal hemisphere blastomere
Conditions:
Assay Type Assay Stages Antibody
histology NF stage 57 to NF stage 58  
Anatomical Phenotypes: abnormal brain morphology
Human Disease Associations: glioblastoma
Source: Fig. 5 C
Article: XB-ART-56659, PubMed