The gene eif6 encodes a cytoplasmic translation initiation factor that binds to the 60S ribosomal subunit and prevents premature association with the 40S subunit, acting as a ribosome anti-association ...[+]

The gene eif6 encodes a cytoplasmic translation initiation factor that binds to the 60S ribosomal subunit and prevents premature association with the 40S subunit, acting as a ribosome anti-association factor essential for proper 60S maturation. It is required for normal development of the cement gland and pronephros, with knockdown leading to defects in these structures and impaired cell proliferation and migration during gastrulation and neurulation. The protein localizes to the nucleus and cytoplasm. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD