The six1 protein is a transcription factor containing a SIX domain and homeodomain, localized to the nucleus. It functions in the formation of cranial placodes, patterning of the otic vesicle, regulati...[+]

The six1 protein is a transcription factor containing a SIX domain and homeodomain, localized to the nucleus. It functions in the formation of cranial placodes, patterning of the otic vesicle, regulation of muscle progenitor cells, and development of the pronephros. Its expression is required for sensory organ development. [-]

             branchiootic syndrome
             autosomal dominant nonsyndromic deafness 23
             branchiootorenal syndrome
             branchiootorenal syndrome 1

          BRANCHIOOTIC SYNDROME 3; BOS3
          DEAFNESS, AUTOSOMAL DOMINANT 23; DFNA23

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD