The dnmt3a gene encodes a DNA methyltransferase that catalyzes de novo DNA methylation during embryogenesis. It is expressed in early developmental stages including gastrula, neurula, and tailbud, with...[+]

The dnmt3a gene encodes a DNA methyltransferase that catalyzes de novo DNA methylation during embryogenesis. It is expressed in early developmental stages including gastrula, neurula, and tailbud, with specific localization in the nervous system, eye, branchial arches, and pronephros. The protein functions in neural crest development and is required for proper craniofacial formation. It localizes to the nucleus and contains a PWWP domain. [-]

             Tatton-Brown-Rahman syndrome

          TATTON-BROWN-RAHMAN SYNDROME; TBRS

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD