The hus1 protein is a checkpoint protein involved in the dna damage response and cell cycle arrest. It forms part of the rad9-hus1-rad1 (9-1-1) clamp complex that localizes to the nucleus and loads ont...[+]

The hus1 protein is a checkpoint protein involved in the dna damage response and cell cycle arrest. It forms part of the rad9-hus1-rad1 (9-1-1) clamp complex that localizes to the nucleus and loads onto damaged dna to activate atr signaling and facilitate DNA repair. Expression is detected in the oocyte, egg, and throughout early embryonic development including during gastrulation and neurulation. [-]

ClinVar, ClinGen, MalaCards, KEGG Disease, DECIPHER, COSMIC, MARRVEL, GTR, DisGeNET, dbVAR, GHR, gnomAD