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XB-PHENO-26967

Xla Wt + xbp1 + DEX, Yang J et al. (2020)

Experiment + Assay: Xla Wt + xbp1 + DEX + NF42 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
mRNA injection xbp1 (Xla) xbp1 (Xla)
 NF stage 3 (4-cell) blastomere
chemical dexamethasone
NF stage 11 whole organism
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 42  
Anatomical Phenotypes: abnormal foregut morphology , abnormal intestine morphology
Expression Phenotypes (4):
decreased amount darmin.L expression in foregut endoderm
decreased amount darmin.L expression in hindgut endoderm
decreased amount hhex.L expression in liver
increased amount ins.L expression in foregut
Source: Fig. 7 A
Article: XB-ART-57472, PubMed