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XB-PHENO-25958

Xla Wt + prdm15 MO + GFP, Mann N et al. (2021)

Experiment + Assay: Xla Wt + prdm15 MO + GFP + NF35/36 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
lineage tracer GFP
NF stage 2 (2-cell)
morpholino injection prdm15 MO1 prdm15 (Xla)
 NF stage 4 (8-cell) ventral vegetal hemisphere blastomere
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 35 and 36  
Expression Phenotypes (10):
absent clcnkb.L expression in distal tubule
absent foxc1.L expression in proximal tubule
absent fxyd2.L expression in distal tubule
decreased amount fxyd2.L expression in pronephric kidney
decreased amount lhx1.L expression in pronephric nephrostome
absent slc12a1.L expression in pronephric kidney
absent slc12a1.L expression in proximal tubule
absent slc5a1.L expression in pronephric tubule
absent slc5a1.L expression in proximal tubule
absent wt1.L expression in glomus
Human Disease Associations: Galloway-Mowat syndrome 1
Source: Fig 3 EFGHIJKL
Article: XB-ART-57819, PubMed