Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
Birth Defects Res A Clin Mol Teratol 2011 Jun 01;916:495-510. doi: 10.1002/bdra.20793.
Show Gene links Show Anatomy links

Xenopus: An emerging model for studying congenital heart disease.

Kaltenbrun E , Tandon P , Amin NM , Waldron L , Showell C , Conlon FL .

Congenital heart defects affect nearly 1% of all newborns and are a significant cause of infant death. Clinical studies have identified a number of congenital heart syndromes associated with mutations in genes that are involved in the complex process of cardiogenesis. The African clawed frog, Xenopus, has been instrumental in studies of vertebrate heart development and provides a valuable tool to investigate the molecular mechanisms underlying human congenital heart diseases. In this review, we discuss the methodologies that make Xenopus an ideal model system to investigate heart development and disease. We also outline congenital heart conditions linked to cardiac genes that have been well studied in Xenopus and describe some emerging technologies that will further aid in the study of these complex syndromes.

PubMed ID: 21538812
PMC ID: PMC3125675
Article link: Birth Defects Res A Clin Mol Teratol
Grant support: [+]

GO keywords: heart development

Disease Ontology terms: congenital heart disease
References [+] :
Abu-Daya, Absence of heartbeat in the Xenopus tropicalis mutation muzak is caused by a nonsense mutation in cardiac myosin myh6. 2009, Pubmed, Xenbase