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Semin Cell Dev Biol 2007 Feb 01;181:46-53. doi: 10.1016/j.semcdb.2006.11.010.
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Xenopus as a model system for vertebrate heart development.

The African clawed frog, Xenopus laevis, is a valuable model system for studies of vertebrate heart development. In the following review, we describe a range of embryological and molecular methodologies that are used in Xenopus research and discuss key discoveries relating to heart development that have been made using this model system. We also discuss how the sequence of the Xenopus tropicalis genome provides a valuable tool for identification of orthologous genes and for identification of evolutionarily conserved promoter elements. Finally, both forward and reverse genetic approaches are currently being applied to Xenopus for the study of vertebrate heart development.

PubMed ID: 17194606
PMC ID: PMC1868678
Article link: Semin Cell Dev Biol
Grant support: [+]

Species referenced: Xenopus tropicalis Xenopus laevis
Genes referenced: myh4 myh6 myl2 myocd nkx2-5 nppa
Morpholinos: myocd MO1 myocd MO2

Phenotypes: Xla Wt + myocd MO (Fig 1. C) [+]

Article Images: [+] show captions
References [+] :
Allen, Transgenic Xenopus laevis embryos can be generated using phiC31 integrase. 2005, Pubmed, Xenbase