Xenbase Image ID: 191265

Fig. 3. In silico screening for candidates with similar properties to SC genes. (A) Schematic of the in silico screen. Known SC disease genes served as an input list. Resource lists represent datasets from various published screening approaches and were tested for enrichment of genes contained in the input list genes. Genes in significantly enriched resource lists were then scored based on membership or rank. The gene scores were statistically validated by an empirical P value based on 10 million random drawings of input list. (B) Whole-mount in situ hybridizations for four candidate genes (c11orf74, cep192, cfap20, and ttc30a) that were experimentally followed up are shown for tadpoles at stage 31 to 35 (nephrostome expression enlarged) and limb buds (stage 55 to 57). (Scale bars, 0.5 mm.) p, posterior; a, anterior; pr, proximal; and d, distal. Image published in: Getwan M et al. (2021) Copyright © 2021. Image reproduced with permission of the publisher and the copyright holder. This is an Open Access article distributed under the terms of the Creative Commons Attribution License. Gene Synonyms Species Stage(s) Tissue iftap.L c11orf74 X. laevis Sometime during NF stage 31 to NF stage 35 and 36 pronephric nephrostome iftap.L c11orf74 X. laevis Sometime during NF stage 55 to NF stage 57 limb bud cfap20.L evorf, fsap23, gtl3 X. laevis Sometime during NF stage 31 to NF stage 35 and 36 head pronephric nephrostome pharyngeal region cfap20.L evorf, fsap23, gtl3 X. laevis Sometime during tadpole stage to NF stage 65 limb bud ift70a.L CFAP259, FAP259, FLJ13946, ttc30a X. laevis Sometime during NF stage 31 to NF stage 35 and 36 head pronephric nephrostome ift70a.L CFAP259, FAP259, FLJ13946, ttc30a X. laevis Sometime during tadpole stage to NF stage 65 limb bud Image source: Published Larger Image Printer Friendly View

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