Fig 2 C abcd

Bou-Rouphael J et al. (2024)

Xla Wt + barhl1

NF45 (in situ hybridization)

Expression Phenotype
increased amount pax6.L expression in rhombomere R1 decreased amount atoh1.L expression in granule cell layer of the cerebellum decreased amount atoh1.L expression in rhombomere R1 increased amount neurod1.L expression in rhombomere R1

Fig 3 A a' a""B C D a

Bou-Rouphael J et al. (2024)

Xla Wt + barhl1 MO

NF45 (in situ hybridization)

Expression Phenotype
absent pax6.L expression in granule cell layer of the cerebellum absent pax6.L expression in rhombomere R1 decreased amount neurod1.L expression in rhombomere R1 increased amount atoh1.L expression in granule cell layer of the cerebellum increased amount atoh1.L expression in rhombic lip

Fig. S3 D

Bou-Rouphael J et al. (2024)

Xla Wt + barhl1 MO

NF48 (in situ hybridization)

Expression Phenotype
decreased amount pax6.L expression in rhombomere R1 decreased amount neurod1.L expression in rhombomere R1 increased amount atoh1.L expression in granule cell layer of the cerebellum

Fig 2 A a a' a'', b b' b'', c; B abcd

Bou-Rouphael J et al. (2024)

Xla wt +tcf7l1-delta_ctnnb1-GR

NF45 (in situ hybridization)

Expression Phenotype
increased amount pax6.L expression in rhombomere R1 decreased amount atoh1.L expression in rhombomere R1 increased amount barhl1.L expression in rhombomere R1 increased amount neurod1.L expression in rhombomere R1

Fig. 2 A

Ismail T et al. (2024)

Xla Wt +PFOS

NF35/36 (in situ hybridization)

Expression Phenotype

increased amount pax6.L expression in eye
increased amount pax6.L expression in forebrain
increased amount pax6.L expression in hindbrain
increased amount pax6.L expression in midbrain-hindbrain boundary
increased amount pax6.L expression in olfactory region
increased amount ldlrap1.L expression in liver primordium
increased amount nkx2-5.L expression in heart
increased amount sox3.L expression in forebrain
increased amount sox3.L expression in midbrain-hindbrain boundary

Fig. 3. B

O'Brien MP et al. (2023)

Xtr Wt + smc5 CRISPR

NF28 (in situ hybridization)

Expression Phenotype
decreased amount pax6 expression in brain decreased amount pax6 expression in eye primordium decreased amount pax6 expression in spinal cord

Fig. S3A r2c1-4

Job F et al. (2023)

Xla Wt + otud3 MO1/2

NF35/36 (in situ hybridization)

Anatomical Phenotype
abnormal eye morphology abnormal head morphology

Expression Phenotype
decreased amount pax6.L expression in forebrain mislocalised pax6.L expression in retina

Fig.6.E-F

Hantel F et al. (2022)

Xla Wt + rmnd5a MO

NF32 (in situ hybridization)

Anatomical Phenotype
abnormal brain abnormal eye decreased size of the eye

Expression Phenotype
decreased amount pax6.L expression in brain decreased amount pax6.L expression in eye

No Image

Fig. 3CD

Flach H et al. (2022)

Xla Wt + glyphosate [121.5]

NF23 (in situ hybridization)

Expression Phenotype
decreased amount pax6.L expression in eye decreased amount rax.L expression in eye

No Image

Fig. 3B

Flach H et al. (2022)

Xla Wt + glyphosate [243]

NF13 (in situ hybridization)

Expression Phenotype
decreased amount pax6.L expression in eye primordium decreased amount rax.L expression in eye primordium decreased amount sox3.L expression in eye primordium