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XB-PHENO-25570

Xla Wt + rmnd5a MO, Hantel F et al. (2022)

Experiment + Assay: Xla Wt + rmnd5a MO + NF32 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
morpholino injection rmnd5a MO1 rmnd5a (Xla)
 NF stage 2 (2-cell) blastomere
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 32 to NF stage 32  
Anatomical Phenotypes: abnormal brain , abnormal eye , decreased size of the eye
Expression Phenotypes (2):
decreased amount pax6.L expression in brain
decreased amount pax6.L expression in eye
Human Disease Associations: neural tube defect, microphthalmia
Source: Fig.6.E-F
Article: XB-ART-59107, PubMed