Fig.5.Col.5

Mukherjee S et al. (2020)

Xtr Wt + ctnnb1 MO

NF10.5 (in situ hybridization)

Expression Phenotype

decreased amount osr1 expression in endoderm
decreased amount osr1 expression in endomesoderm
decreased amount dkk1 expression in dorsal endoderm
decreased amount dkk1 expression in dorsal endomesoderm
decreased amount foxa1 expression in endoderm
decreased amount foxa1 expression in ventral marginal zone
decreased amount lhx5 expression in animal cap
decreased amount lhx5 expression in ectoderm
decreased amount six1 expression in dorsal endoderm
decreased amount six1 expression in dorsal endomesoderm

Fig.3.S1.C

Mukherjee S et al. (2020)

Xtr Wt + ctnnb1 MO

NF35/36 (in situ hybridization)

Anatomical Phenotype
wholly ventralized embryo

Expression Phenotype
absent osr1 expression in embryo absent isl1 expression in embryo absent nr1h5 expression in embryo

Fig.1.F

Mukherjee S et al. (2020)

Xtr Wt + sox17a MO + sox17b.1/b.2 MO

NF10.5 (in situ hybridization)

Expression Phenotype

decreased amount osr1 expression in endoderm
decreased amount osr1 expression in endomesoderm
decreased amount hnf1b expression in central endoderm
decreased amount hnf1b expression in endoderm
decreased amount slc5a8.1 expression in involuting marginal zone
decreased amount slc5a8.1 expression in upper blastopore lip
increased amount gdf3 expression in endoderm
increased amount nodal3.1 expression in central endoderm
increased amount nodal3.1 expression in involuting marginal zone
increased amount nodal3.1 expression in ventral marginal zone
increased amount tfap2a expression in marginal zone

Fig.5.Col.2

Mukherjee S et al. (2020)

Xtr Wt + sox17a MO + sox17b.1/b.2 MO

NF10.5 (in situ hybridization)

Expression Phenotype

decreased amount osr1 expression in endoderm
decreased amount osr1 expression in endomesoderm
decreased amount foxa1 expression in endoderm
decreased amount foxa1 expression in ventral marginal zone
decreased amount six1 expression in dorsal endoderm
decreased amount six1 expression in dorsal endomesoderm
increased amount dkk1 expression in central endoderm
increased amount dkk1 expression in endomesoderm
increased amount lhx5 expression in endoderm

Fig.1.S1.C

Mukherjee S et al. (2020)

Xtr Wt + sox17a MO + sox17b.1/b.2 MO

NF35/36 (in situ hybridization)

Expression Phenotype

decreased amount osr1 expression in cement gland
decreased amount osr1 expression in intestine
decreased amount osr1 expression in lung
decreased amount osr1 expression in stomach
decreased amount isl1 expression in eye
decreased amount isl1 expression in intestine
decreased amount isl1 expression in pharyngeal region
decreased amount isl1 expression in pharynx
decreased amount isl1 expression in profundus ganglion
decreased amount nr1h5 expression in liver
decreased amount nr1h5 expression in pharyngeal region

fig.4.d

Rankin SA et al. (2012)

Xtr Wt + BMS493

NF35/36 (in situ hybridization)

Expression Phenotype
decreased amount osr1 expression in foregut decreased amount aldh1a2 expression in lateral plate mesoderm decreased amount osr2 expression in foregut decreased amount sox2 expression in foregut decreased amount wnt2b expression in lateral plate mesoderm

fig.4.b

Rankin SA et al. (2012)

Xtr Wt + PD173074

NF35/36 (in situ hybridization)

Expression Phenotype
decreased amount osr1 expression in foregut decreased amount nkx2-1 expression in head decreased amount nkx2-1 expression in lung bud decreased amount osr2 expression in foregut decreased amount sox2 expression in foregut decreased amount wnt2b expression in lateral plate mesoderm