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XB-PHENO-25430

Xtr Wt + sox17a MO + sox17b.1/b.2 MO, Mukherjee S et al. (2020)

Experiment + Assay: Xtr Wt + sox17a MO + sox17b.1/b.2 MO + NF10.5 (in situ hybridization)
Background: Xtr.NigerianNasco
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
morpholino injection sox17b.1/b.2 MO1 sox17b.2
sox17b.1
 NF stage 2- blastomere
morpholino injection sox17a MO5 sox17a
 NF stage 2- blastomere
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 10.5  
Expression Phenotypes (11):
increased amount gdf3 expression in endoderm
decreased amount hnf1b expression in central endoderm
decreased amount hnf1b expression in endoderm
increased amount nodal3.1 expression in central endoderm
increased amount nodal3.1 expression in involuting marginal zone
increased amount nodal3.1 expression in ventral marginal zone
decreased amount osr1 expression in endoderm
decreased amount osr1 expression in endomesoderm
decreased amount slc5a8.1 expression in involuting marginal zone
decreased amount slc5a8.1 expression in upper blastopore lip
increased amount tfap2a expression in marginal zone
Source: Fig.1.F
Article: XB-ART-57340, PubMed