Kumar S , Kumar V , Li W , Kim J .

BB/T003146/1 Biotechnology and Biological Sciences Research Council , 2016R1D1A1B02008770 and 2021M3H9A1097557 National Research Foundation of Korea

	Figure 1. Chromosomal localization of Ventx gene synteny in humans and other animal species relative to adjacent genes (color-coded).
	Figure 2. Schematic representation of conserved domains and motifs associated with different classes of HD proteins in animals. This figure was adapted from Burglin et al. (2016) [9].
	Figure 3. Schematic representations of Ventx domains in Xenopus laevis, zebrafish, and humans. (A) All Ventx members contain a transactivation domain (green), a highly conserved homeobox DNA-binding domain (HD, 60 aa, pink), and a repressor domain (grey), which inhibits the expression of dorsal-specific genes such as gsc, chordin, and boz/dha. The N-terminal domain (ND) of the Ventx family acts as a transactivation domain (TAD) to activate ventral-specific genes such as bmp4, ventx1.1, ventx1.2, Ventx2.2, and Ventx2.2. (B) An evolutionary phylogenetic tree of the Ventx gene cluster in Xenopus laevis. (C) An evolutionary phylogenetic tree of the vega/ventx gene cluster in zebrafish. (B’,C’) The percentage-identity matrix of Ventx family members in Xenopus and zebrafish.
	Figure 4. Upstream and downstream regulatory pathways for Ventx members during Xenopus laevis and zebrafish embryonic development and the potential functions of Ventx in human hematopoiesis, cell differentiation, and leukemogenesis. Lines with arrows indicate promoting and those with bars suppressing (functions of) the targets. Indirect targets of Ventx family members are in red. Sign (?) indicates unknown factors.

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