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Dev Dyn 2008 Aug 01;2378:2177-86. doi: 10.1002/dvdy.21631.
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Bmp signaling is necessary and sufficient for ventrolateral endoderm specification in Xenopus.

Wills A , Dickinson K , Khokha M , Baker JC .

Here we show that Bmp signaling is necessary and sufficient for the specification of ventral endoderm in Xenopus embryos. Overexpression of Bmp4 in ectoderm induces markers of endoderm, including Sox17beta, Mixer, and VegT, but cannot induce the expression of the dorsoanterior markers, Xhex and Cerberus. Furthermore, knockdown approaches using overexpression of Bmp antagonists and morpholinos designed against Bmp4, Bmp2, and Bmp7 demonstrate that Bmp signaling is critical for ventral, but not dorsoanterior endoderm formation. This activity is not simply a result of embryonic dorsalization as markers for dorsal endoderm are not expanded. We further show that endodermal cells of either ventral or dorsal character do not form when both Wnt and Bmp signals are abolished. Overall, this report strongly suggests that Bmp plays an essential role in ventral endoderm specification.

PubMed ID: 18651654
PMC ID: PMC4497515
Article link: Dev Dyn
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: bmp2 bmp4 bmp7.1 bmp7.2 bmpr1a cer1 chrd gal.2 gdf3 hhex mixer myf5 nog sox17a sox17b.1 sox17b.2 tbxt vegt ventx2.2

Article Images: [+] show captions
References [+] :
Agius, Endodermal Nodal-related signals and mesoderm induction in Xenopus. 2000, Pubmed, Xenbase