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Biochem Biophys Res Commun 1992 Aug 14;1863:1487-95.
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Genes for bone morphogenetic proteins are differentially transcribed in early amphibian embryos.

Nishimatsu S , Suzuki A , Shoda A , Murakami K , Ueno N .

We have previously demonstrated that activin, a member of the TGF-beta family, has a potent mesoderm-inducing activity in Xenopus embryos. In the course of screening for activin-related genes from Xenopus, we have cloned cDNAs for Xenopus homologue of BMP-2, -4 and -7. Northern blot analysis revealed that these BMP genes are maternally encoded and differentially regulated after fertilization. Alkaline phosphatase-inducing assay using the recombinant BMP proteins has shown that at least BMP-2 and -4 have similar activity to mammalian counterparts.

PubMed ID: 1510675
Article link: Biochem Biophys Res Commun