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J Cell Sci 2018 Jan 29;1313:. doi: 10.1242/jcs.206565.
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Protein localization screening in vivo reveals novel regulators of multiciliated cell development and function.

Tu F , Sedzinski J , Ma Y , Marcotte EM , Wallingford JB .

Multiciliated cells (MCCs) drive fluid flow in diverse tubular organs and are essential for the development and homeostasis of the vertebrate central nervous system, airway and reproductive tracts. These cells are characterized by dozens or hundreds of motile cilia that beat in a coordinated and polarized manner. In recent years, genomic studies have not only elucidated the transcriptional hierarchy for MCC specification but also identified myriad new proteins that govern MCC ciliogenesis, cilia beating and cilia polarization. Interestingly, this burst of genomic data has also highlighted that proteins with no obvious role in cilia do, in fact, have important ciliary functions. Understanding the function of proteins with little prior history of study presents a special challenge, especially when faced with large numbers of such proteins. Here, we define the subcellular localization in MCCs of ∼200 proteins not previously implicated in cilia biology. Functional analyses arising from the screen provide novel links between actin cytoskeleton and MCC ciliogenesis.

PubMed ID: 29180514
PMC ID: PMC5826043
Article link: J Cell Sci
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: arfgap3 c7h10orf88 ccp110 cep164 cetn4 dennd2b eef1a2 efhc2 galt ift20 mcc ptk2 rfx2 ttbk2
GO keywords: cytosolic ciliogenesis


Article Images: [+] show captions
References [+] :
Ahmed, Mutations of LRTOMT, a fusion gene with alternative reading frames, cause nonsyndromic deafness in humans. 2008, Pubmed