Xtr Wt + fgfr4 CRISPR
has
14
phenotype(s)
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Experiment + Assay
Phenotypes
Human Diseases
Fig. 5 E
Sempou E et al. (2018)
Xtr Wt + fgfr4 CRISPR
NF10 (in situ hybridization)
Expression Phenotype
decreased amount
myf5
expression in mesoderm
congenital heart disease
visceral heterotaxy
Fig. 5 H
Sempou E et al. (2018)
Xtr Wt + fgfr4 CRISPR
NF12 (in situ hybridization)
Expression Phenotype
decreased amount
myf5
expression in presumptive paraxial mesoderm
congenital heart disease
visceral heterotaxy
Fig. 5 I
Sempou E et al. (2018)
Xtr Wt + fgfr4 CRISPR
NF12 (in situ hybridization)
Expression Phenotype
decreased amount
myod1
expression in presumptive paraxial mesoderm
congenital heart disease
visceral heterotaxy
Fig. 5 L
Sempou E et al. (2018)
Xtr Wt + fgfr4 CRISPR
NF12 (in situ hybridization)
Expression Phenotype
decreased amount
tbxt
expression in presumptive paraxial mesoderm
congenital heart disease
visceral heterotaxy
Fig. 3 A-H, L, M
Sempou E et al. (2018)
Xtr Wt + fgfr4 CRISPR
NF17 (immunohistochemistry)
Anatomical Phenotype
abnormal gastrocoel roof plate morphology
abnormal left-right organizer morphology
abnormally decreased number of cilium in the left-right organizer
congenital heart disease
visceral heterotaxy
Fig. 3 I-K
Sempou E et al. (2018)
Xtr Wt + fgfr4 CRISPR
NF17 (immunohistochemistry)
Anatomical Phenotype
abnormal gastrocoel roof plate morphology
abnormal left-right organizer morphology
decreased size of the presomitic mesoderm
Expression Phenotype
decreased amount
myod1
expression in gastrocoel roof plate
decreased amount
myod1
expression in left-right organizer
congenital heart disease
visceral heterotaxy
Fig. S 2 A, B
Sempou E et al. (2018)
Xtr Wt + fgfr4 CRISPR
NF17 (immunohistochemistry)
Anatomical Phenotype
abnormal gastrocoel roof plate morphology
abnormal left-right organizer morphology
abnormally decreased number of cilium in the left-right organizer
Expression Phenotype
decreased amount
tuba4b
expression in left-right organizer
congenital heart disease
visceral heterotaxy
Fig. 2 A
Sempou E et al. (2018)
Xtr Wt + fgfr4 CRISPR
NF17 (in situ hybridization)
Expression Phenotype
decreased amount
dand5
expression in left-right organizer
congenital heart disease
visceral heterotaxy
Fig. 2 C
Sempou E et al. (2018)
Xtr Wt + fgfr4 CRISPR
NF17 (in situ hybridization)
Expression Phenotype
decreased amount
nodal1
expression in left-right organizer
congenital heart disease
visceral heterotaxy
Fig. 2 E
Sempou E et al. (2018)
Xtr Wt + fgfr4 CRISPR
NF17 (in situ hybridization)
Expression Phenotype
decreased amount
gdf3
expression in left-right organizer
congenital heart disease
visceral heterotaxy