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XB-PHENO-24271

Xtr Wt + fgfr4 CRISPR, Sempou E et al. (2018)

Experiment + Assay: Xtr Wt + fgfr4 CRISPR + NF17 (immunohistochemistry)
Background: Xtr.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
CRISPR fgfr4 fgfr4
 NF stage 1 zygote
Conditions:
Assay Type Assay Stages Antibody
immunohistochemistry NF stage 17 to NF stage 17 Tuba4a Ab15
Anatomical Phenotypes: abnormal gastrocoel roof plate morphology, abnormal left-right organizer morphology, abnormally decreased number of cilium in the left-right organizer
Expression Phenotypes (1):
decreased amount tuba4b expression in left-right organizer
Human Disease Associations: congenital heart disease, visceral heterotaxy
Source: Fig. S 2 A, B
Article: XB-ART-55550, PubMed