Fig. 2. Xenopus laevis SoxCs exhibit overlapping expression in the neural plate, neural crest, and facial region. Sox4 (St.14â28) is expressed broadly in the neural plate starting at stage 14/15 and in the forming neural tube and migrating neural crest (Dorsal: AâC). It is then strongly expressed in developing ganglia as well as weakly in the branchial arches, otic vesicle, and eye (D and E). Sox11 (St.14â28) is strongly expressed early in the neural plate border and neural folds (Dorsal:H). It is expressed in neural crest and ectodermal placodes (Dorsal:FâJ). Expression is maintained in the neural tube, forming ganglia, and branchial arches (I and J). Sox12 (st.14â28) is expressed broadly and similarly to Sox4. At St 14â20, Sox12 is expressed throughout the neural plate and in the migrating neural crest (Dorsal:KâM). Expression is observed throughout the neural tube as well as in cranial ganglia, branchial arches, eye, and otic vesicle (N and O). Ot: Otic Vesicle; BA: Branchial Arches.
Image published in: Uy BR et al. (2015)
Copyright © 2015. Image reproduced with permission of the Publisher, Elsevier B. V.
| Gene | Synonyms | Species | Stage(s) | Tissue |
|---|---|---|---|---|
| sox4.L | sox4-a, sox4-b | X. laevis | Throughout NF stage 14 | neural plate pre-chordal neural plate chordal neural plate anterior neural fold |
| sox11.L | sox11-a, sox11-b, XLS13, xls13a, XLS13b, xSOX-11, xsox11 | X. laevis | Sometime during NF stage 14 to NF stage 17 | neural plate pre-chordal neural plate chordal neural plate anterior neural fold preplacodal ectoderm posterior placodal area |
| sox12.S | sox-K1, xSox33, xSox-K1 | X. laevis | Sometime during NF stage 14 to NF stage 17 | neural plate pre-chordal neural plate chordal neural plate anterior neural fold optic field |
| sox4.L | sox4-a, sox4-b | X. laevis | Throughout NF stage 17 | neural plate cranial neural crest mandibular crest hyoid crest branchial crest |
| sox4.L | sox4-a, sox4-b | X. laevis | Throughout NF stage 20 | optic vesicle neural tube posterior neural tube anterior neural tube stomodeal-hypophyseal primordium cranial neural crest mandibular crest hyoid crest branchial crest |
| sox11.L | sox11-a, sox11-b, XLS13, xls13a, XLS13b, xSOX-11, xsox11 | X. laevis | Throughout NF stage 20 | neural tube posterior neural tube anterior neural tube optic vesicle |
| sox12.S | sox-K1, xSox33, xSox-K1 | X. laevis | Throughout NF stage 20 | neural tube cranial neural crest posterior neural tube anterior neural tube optic vesicle |
| sox4.L | sox4-a, sox4-b | X. laevis | Sometime during NF stage 26 to NF stage 28 | eye otic vesicle cranial neural crest mandibular crest hyoid crest anterior branchial crest posterior branchial crest pharyngeal arch mandibular arch hyoid arch branchial arch forebrain midbrain hindbrain brain |
| sox12.S | sox-K1, xSox33, xSox-K1 | X. laevis | Sometime during NF stage 26 to NF stage 28 | branchial arch otic vesicle eye cranial neural crest mandibular crest hyoid crest branchial crest pharyngeal arch mandibular arch hyoid arch optic vesicle |
| sox11.L | sox11-a, sox11-b, XLS13, xls13a, XLS13b, xSOX-11, xsox11 | X. laevis | Throughout NF stage 26 to NF stage 28 | pharyngeal arch cranial ganglion branchial arch eye branchial crest optic vesicle brain forebrain midbrain hindbrain |
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