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Nat Commun 2023 Dec 11;141:8199. doi: 10.1038/s41467-023-43902-y.
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An archetype and scaling of developmental tissue dynamics across species.

Morishita Y , Lee SW , Suzuki T , Yokoyama H , Kamei Y , Tamura K , Kawasumi-Kita A .

Morphometric studies have revealed the existence of simple geometric relationships among various animal shapes. However, we have little knowledge of the mathematical principles behind the morphogenetic dynamics that form the organ/body shapes of different species. Here, we address this issue by focusing on limb morphogenesis in Gallus gallus domesticus (chicken) and Xenopus laevis (African clawed frog). To compare the deformation dynamics between tissues with different sizes/shapes as well as their developmental rates, we introduce a species-specific rescaled spatial coordinate and a common clock necessary for cross-species synchronization of developmental times. We find that tissue dynamics are well conserved across species under this spacetime coordinate system, at least from the early stages of development through the phase when basic digit patterning is established. For this developmental period, we also reveal that the tissue dynamics of both species are mapped with each other through a time-variant linear transformation in real physical space, from which hypotheses on a species-independent archetype of tissue dynamics and morphogenetic scaling are proposed.

PubMed ID: 38081837
PMC ID: PMC10713982
Article link: Nat Commun
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: clock hoxa11 hoxa13 hoxd13 shh
GO keywords: limb development

Article Images: [+] show captions
References [+] :
Abzhanov, The old and new faces of morphology: the legacy of D'Arcy Thompson's 'theory of transformations' and 'laws of growth'. 2017, Pubmed