Click here to close Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly. We suggest using a current version of Chrome, FireFox, or Safari.
XB-ART-60289
Nanomaterials (Basel) 2023 Sep 04;1317:. doi: 10.3390/nano13172488.
Show Gene links Show Anatomy links

Adverse Effect of Metallic Gold and Silver Nanoparticles on Xenopus laevis Embryogenesis.

Carotenuto R , Tussellino M , Fusco S , Benvenuto G , Formiggini F , Avallone B , Motta CM , Fogliano C , Netti PA .


Abstract
Exposure to metal nanoparticles is potentially harmful, particularly when occurring during embryogenesis. In this study, we tested the effects of commercial AuNPs and AgNPs, widely used in many fields for their features, on the early development of Xenopus laevis, an anuran amphibian key model species in toxicity testing. Through the Frog Embryo Teratogenesis Assay-Xenopus test (FETAX), we ascertained that both nanoparticles did not influence the survival rate but induced morphological anomalies like modifications of head and branchial arch cartilages, depigmentation of the dorsal area, damage to the intestinal brush border, and heart rate alteration. The expression of genes involved in the early pathways of embryo development was also modified. This study suggests that both types of nanoparticles are toxic though nonlethal, thus indicating that their use requires attention and further study to better clarify their activity in animals and, more importantly, in humans.

PubMed ID: 37686995
PMC ID: PMC10489621
Article link: Nanomaterials (Basel)


Species referenced: Xenopus laevis
Genes referenced: bmp4 egr2 fgf8 nps pax6 rax sox9
GO keywords: embryo development


Article Images: [+] show captions
References [+] :
Ahamed, Silver nanoparticle applications and human health. 2010, Pubmed