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Chemosphere 2022 Feb 01;289:133233. doi: 10.1016/j.chemosphere.2021.133233.
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Toxic effects of SiO2NPs in early embryogenesis of Xenopuslaevis.

Carotenuto R , Tussellino M , Ronca R , Benvenuto G , Fogliano C , Fusco S , Netti PA .

The exposure of organisms to the nanoparticulate is potentially hazardous, particularly when it occurs during embryogenesis. The effects of commercial SiO2NPs in early development were studied, using Xenopus laevis as a model to investigate their possible future employment by means of the Frog Embryo Teratogenesis Assay-Xenopus test (FETAX). The SiO2NPs did not change the survival but produced several abnormalities in developing embryos, in particular, the dorsal pigmentation, the cartilages of the head and branchial arches were modified; the encephalon, spinal cord and nerves are anomalous and the intestinal brush border show signs of suffering; these embryos are also bradycardic. In addition, the expression of genes involved in the early pathways of embryo development was modified. Treated embryos showed an increase of reactive oxygen species. This study suggests that SiO2NPs are toxic but non-lethal and showed potential teratogenic effects in Xenopus. The latter may be due to their cellular accumulation and/or to the effect caused by the interaction of SiO2NPs with cytoplasmic and/or nuclear components. ROS production could contribute to the observed effects. In conclusion, the data indicates that the use of SiO2NPs requires close attention and further studies to better clarify their activity in animals, including humans.

PubMed ID: 34896176
Article link: Chemosphere

Species referenced: Xenopus laevis
Genes referenced: bmp4 egr2 fgf8 odc1 pax6 rax sox9
Antibodies: Tuba4b Ab5