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Evol Dev 2020 Jul 01;224:297-311. doi: 10.1111/ede.12332.
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von Willebrand factor D and EGF domains is an evolutionarily conserved and required feature of blastemas capable of multitissue appendage regeneration.

Leigh ND , Sessa S , Dragalzew AC , Payzin-Dogru D , Sousa JF , Aggouras AN , Johnson K , Dunlap GS , Haas BJ , Levin M , Schneider I , Whited JL .

Regenerative ability varies tremendously across species. A common feature of regeneration of appendages such as limbs, fins, antlers, and tails is the formation of a blastema-a transient structure that houses a pool of progenitor cells that can regenerate the missing tissue. We have identified the expression of von Willebrand factor D and EGF domains (vwde) as a common feature of blastemas capable of regenerating limbs and fins in a variety of highly regenerative species, including axolotl (Ambystoma mexicanum), lungfish (Lepidosiren paradoxa), and Polpyterus (Polypterus senegalus). Further, vwde expression is tightly linked to the ability to regenerate appendages in Xenopus laevis. Functional experiments demonstrate a requirement for vwde in regeneration and indicate that Vwde is a potent growth factor in the blastema. These data identify a key role for vwde in regenerating blastemas and underscore the power of an evolutionarily informed approach for identifying conserved genetic components of regeneration.

PubMed ID: 32163674
PMC ID: PMC7390686
Article link: Evol Dev
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: egf
GO keywords: regeneration [+]

Article Images: [+] show captions
References [+] :
Aztekin, Identification of a regeneration-organizing cell in the Xenopus tail. 2019, Pubmed, Xenbase