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Nature 2016 Mar 10;5317593:237-40. doi: 10.1038/nature16974.
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MARCKS-like protein is an initiating molecule in axolotl appendage regeneration.

Sugiura T , Wang H , Barsacchi R , Simon A , Tanaka EM .

Identifying key molecules that launch regeneration has been a long-sought goal. Multiple regenerative animals show an initial wound-associated proliferative response that transits into sustained proliferation if a considerable portion of the body part has been removed. In the axolotl, appendage amputation initiates a round of wound-associated cell cycle induction followed by continued proliferation that is dependent on nerve-derived signals. A wound-associated molecule that triggers the initial proliferative response to launch regeneration has remained obscure. Here, using an expression cloning strategy followed by in vivo gain- and loss-of-function assays, we identified axolotl MARCKS-like protein (MLP) as an extracellularly released factor that induces the initial cell cycle response during axolotl appendage regeneration. The identification of a regeneration-initiating molecule opens the possibility of understanding how to elicit regeneration in other animals.

PubMed ID: 26934225
PMC ID: PMC4795554
Article link: Nature
Grant support: [+]

Species referenced: Xenopus
Genes referenced: gnl3 marcks marcksl1

Article Images: [+] show captions
References [+] :
Aderem, The MARCKS brothers: a family of protein kinase C substrates. 1992, Pubmed