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Development 2018 Jun 08;14512:. doi: 10.1242/dev.161372.
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Retinoic acid-induced expression of Hnf1b and Fzd4 is required for pancreas development in Xenopus laevis.

Gere-Becker MB , Pommerenke C , Lingner T , Pieler T .

Retinoic acid (RA) is required for pancreas specification in Xenopus and other vertebrates. However, the gene network that is directly induced by RA signalling in this context remains to be defined. By RNA sequencing of in vitro-generated pancreatic explants, we identified the genes encoding the transcription factor Hnf1β and the Wnt-receptor Fzd4/Fzd4s as direct RA target genes. Functional analyses of Hnf1b and Fzd4/Fzd4s in programmed pancreatic explants and whole embryos revealed their requirement for pancreatic progenitor formation and differentiation. Thus, Hnf1β and Fzd4/Fzd4s appear to be involved in pre-patterning events of the embryonic endoderm that allow pancreas formation in Xenopus.

PubMed ID: 29769220
PMC ID: PMC6031401
Article link: Development

Species referenced: Xenopus laevis
Genes referenced: aldh1a2 bmp4 cebpd cer1 chrd cyp26a1 darmin dhrs3 dusp5 fabp2 foxh1 fst fzd4 gbx2.1 gcg hhex hnf1b hnf4a hoxa1 hoxb1 hoxb3 hoxd1 hoxd4 igf3 ins kremen2 krt12.4 lhx1 mcf2 meis3 nkx2-1 nkx6-2 nog odc1 pdia2 pdx1 prph psmd6 ptf1a rara sox17a sox2 tesk1 vegt znf703
GO keywords: pancreas development [+]
Morpholinos: Fzd4 MO1 hnf1b MO1

GEO Series: GSE112718: Xenbase,  NCBI

Article Images: [+] show captions
References [+] :
Abu-Abed, Mouse P450RAI (CYP26) expression and retinoic acid-inducible retinoic acid metabolism in F9 cells are regulated by retinoic acid receptor gamma and retinoid X receptor alpha. 1998, Pubmed