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Regeneration (Oxf) 2014 May 28;12:26-36. doi: 10.1002/reg2.11.
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Ectopic blastema induction by nerve deviation and skin wounding: a new regeneration model in Xenopus laevis.

Mitogawa K , Hirata A , Moriyasu M , Makanae A , Miura S , Endo T , Satoh A .

Recently, the accessory limb model (ALM) has become an alternative study system for limb regeneration studies in axolotls instead of using an amputated limb. ALM progresses limb regeneration study in axolotls because of its advantages. To apply and/or to compare knowledge in axolotl ALM studies to other vertebrates is a conceivable next step. First, Xenopus laevis, an anuran amphibian, was investigated. A Xenopus frog has hypomorphic regeneration ability. Its regeneration ability has been considered intermediate between that of non-regenerative higher vertebrates and regenerative urodele amphibians. Here, we successfully induced an accessory blastema in Xenopus by skin wounding and rerouting of brachial nerve bundles to the wound site, which is the regular ALM surgery. The induced Xenopus ALM blastemas have limited regenerative potential compared with axolotl ALM blastemas. Comparison of ALM blastemas from species with different regenerative potentials may facilitate the identification of the novel expression programs necessary for the formation of cartilage and other tissues during limb regeneration.

PubMed ID: 27499859
PMC ID: PMC4895307
Article link: Regeneration (Oxf)

Species referenced: Xenopus laevis
Genes referenced: bmp2 fgf10 fgf8 fn1 hoxa13 myh6 prrx1 sox9

Article Images: [+] show captions
References [+] :
Cannata, Nerve-independence of limb regeneration in larval Xenopus laevis is correlated to the level of fgf-2 mRNA expression in limb tissues. 2001, Pubmed, Xenbase