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ScientificWorldJournal 2006 May 12;6 Suppl 1:26-37. doi: 10.1100/tsw.2006.325.
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Limb regeneration in Xenopus laevis froglet.

Suzuki M , Yakushiji N , Nakada Y , Satoh A , Ide H , Tamura K .

Limb regeneration in amphibians is a representative process of epimorphosis. This type of organ regeneration, in which a mass of undifferentiated cells referred to as the "blastema" proliferate to restore the lost part of the amputated organ, is distinct from morphallaxis as observed, for instance, in Hydra, in which rearrangement of pre-existing cells and tissues mainly contribute to regeneration. In contrast to complete limb regeneration in urodele amphibians, limb regeneration in Xenopus, an anuran amphibian, is restricted. In this review of some aspects regarding adult limb regeneration in Xenopus laevis, we suggest that limb regeneration in adult Xenopus, which is pattern/tissue deficient, also represents epimorphosis.

PubMed ID: 17205185
PMC ID: PMC5917240
Article link: ScientificWorldJournal

Species referenced: Xenopus laevis
Genes referenced: bmp4 fgf10 fgf8 gdf5 hoxa11 hoxa13 lmx1a mhc2-dab mmp10 mmp3 msx1 myf5 myod1 pax7 prrx1 prx scx shh tbx2 tbx5 twist1 zp2
GO keywords: regeneration [+]

Article Images: [+] show captions