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Cell Mol Life Sci 2012 Nov 01;6922:3715-37. doi: 10.1007/s00018-012-0991-8.
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Current perspectives of the signaling pathways directing neural crest induction.

Stuhlmiller TJ , García-Castro MI .

The neural crest is a migratory population of embryonic cells with a tremendous potential to differentiate and contribute to nearly every organ system in the adult body. Over the past two decades, an incredible amount of research has given us a reasonable understanding of how these cells are generated. Neural crest induction involves the combinatorial input of multiple signaling pathways and transcription factors, and is thought to occur in two phases from gastrulation to neurulation. In the first phase, FGF and Wnt signaling induce NC progenitors at the border of the neural plate, activating the expression of members of the Msx, Pax, and Zic families, among others. In the second phase, BMP, Wnt, and Notch signaling maintain these progenitors and bring about the expression of definitive NC markers including Snail2, FoxD3, and Sox9/10. In recent years, additional signaling molecules and modulators of these pathways have been uncovered, creating an increasingly complex regulatory network. In this work, we provide a comprehensive review of the major signaling pathways that participate in neural crest induction, with a focus on recent developments and current perspectives. We provide a simplified model of early neural crest development and stress similarities and differences between four major model organisms: Xenopus, chick, zebrafish, and mouse.

PubMed ID: 22547091
PMC ID: PMC3478512
Article link: Cell Mol Life Sci
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: bmp4 bmp7.1 bmp7.2 ctnnb1 dlx3 eno1 fgf8 foxd3 hes4 id3 ihh mapk1 mapk8 msx1 myc notch1 npb pax3 pax7 pnp rho rho.2 shh smad1 snai2 sox9 tfap2a twist1 wnt1 wnt3a wnt6 wnt8a zic1

Article Images: [+] show captions
References [+] :
Abu-Elmagd, Frizzled7 mediates canonical Wnt signaling in neural crest induction. 2006, Pubmed, Xenbase