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Dev Dyn 2009 Sep 01;2389:2340-56. doi: 10.1002/dvdy.21998.
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Gene expression profiles of lens regeneration and development in Xenopus laevis.

Malloch EL , Perry KJ , Fukui L , Johnson VR , Wever J , Beck CW , King MW , Henry JJ .

Seven hundred and thirty-four unique genes were recovered from a cDNA library enriched for genes up-regulated during the process of lens regeneration in the frog Xenopus laevis. The sequences represent transcription factors, proteins involved in RNA synthesis/processing, components of prominent cell signaling pathways, genes involved in protein processing, transport, and degradation (e.g., the ubiquitin/proteasome pathway), matrix metalloproteases (MMPs), as well as many other proteins. The findings implicate specific signal transduction pathways in the process of lens regeneration, including the FGF, TGF-beta, MAPK, Retinoic acid, Wnt, and hedgehog signaling pathways, which are known to play important roles in eye/lens development and regeneration in various systems. In situ hybridization revealed that the majority of genes recovered are expressed during embryogenesis, including in eye tissues. Several novel genes specifically expressed in lenses were identified. The suite of genes was compared to those up-regulated in other regenerating tissues/organisms, and a small degree of overlap was detected.

PubMed ID: 19681139
PMC ID: PMC2773617
Article link: Dev Dyn
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: anos1 ckb cmtm5 cryba1 crygdl.30 crygdl.43 crygn gpr84 ids ino80d lmo4.1 lmo4.2 mapk1 mmp1 pax7 paxbp1 pheta2 prpf39.1 prps1 pym1 shh smpd3 taf9b tgfb1
GO keywords: lens development in camera-type eye [+]

Article Images: [+] show captions
References [+] :
Altschul, Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. 1997, Pubmed