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Dev Dyn 2004 Aug 01;2304:615-29. doi: 10.1002/dvdy.20089.
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Early regeneration genes: Building a molecular profile for shared expression in cornea-lens transdifferentiation and hindlimb regeneration in Xenopus laevis.

Wolfe AD , Crimmins G , Cameron JA , Henry JJ .

Recent studies in Xenopus laevis have begun to compare gene expression during regeneration with that of the original development of specific structures (e.g., the hindlimb and lens), while other studies have sought differences in gene expression between regeneration-competent and regeneration-incompetent stages. To determine whether there are any similarities between the regeneration of different structures, we have used a differential screen to seek shared early gene expression between hindlimb regeneration and cornea-lens transdifferentiation in the Xenopus tadpole. We have isolated 13 clones representing genes whose expression is up-regulated within the first few days of both regenerating processes and which are not demonstrably up-regulated in the context of basic wound healing. Furthermore, all of these genes also show prominent late embryonic expression. The expression patterns and putative identities of all 13 genes are presented, and a model is considered that allows us to characterize and profile important changes in gene expression, which might be shared among various regenerating and developmental systems.

PubMed ID: 15254896
Article link: Dev Dyn
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: aifm2 ccdc50 dimt1 dnaaf5 lrrn1 lrrn1l pjvk rbm17 rpf2 wnt5b

Article Images: [+] show captions