Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
A sharp retinal image increases the topographic precision of the goldfish retinotectal projection during optic nerve regeneration in stroboscopic light.
Cook JE
.
???displayArticle.abstract???
Locally-correlated neural activity appears to play a key role in refining topographically mapped projections. The retinotectal projection of the goldfish normally regains a high degree of spatial precision after regeneration of a cut optic nerve, but it fails to do so if retinal ganglion cell activity is blocked by tetrodotoxin, or if local correlations in activity are masked by the synchronizing effect of stroboscopic light. A sharp retinal image is not normally needed for a sharp map because local correlation occurs even in darkness or diffuse light, but the possibility that a sharp image might restore local correlation and sharpen the map in stroboscopic light, though taken into account in earlier experiments, has not previously been tested. The precision of the retinotectal map was therefore studied, by retrograde transport of WGA-HRP from a standard tectal injection site and quantitative analysis of the labelled ganglion cell distribution, after regeneration of a cut optic nerve for 83-84 days in either continuous stroboscopic light or normal diurnal light. The lens of the eye was either ablated to blur the retinal image or sham-operated. Two different strobe flash patterns used in previous experiments were also compared. With the lens ablated, stroboscopic light impaired map refinement significantly, confirming previous results. A rapid, irregular flash pattern averaging about 5 Hz was rather more effective than a regular 1 Hz pattern. With the lens intact, however, neither pattern had any detectable effect. The significant gain in precision resulting from a sharp retinal image in these circumstances suggests that common mechanisms could underlie both the internal refinement of the retinotectal map and such directly experience-sensitive processes as the experimental realignment of binocular maps in the frog Xenopus, and of auditory and visual maps in the barn owl.
Arnett,
Statistical dependence between neighboring retinal ganglion cells in goldfish.
1978, Pubmed
Arnett,
Statistical dependence between neighboring retinal ganglion cells in goldfish.
1978,
Pubmed
Arnett,
Cross-correlation analysis of the maintained discharge of rabbit retinal ganglion cells.
1981,
Pubmed
Charman,
The opitcal system of the goldfish eye.
1973,
Pubmed
Chung,
In search of the rules for nerve connections.
1974,
Pubmed
Cook,
Impaired refinement of the regenerated retinotectal projection of the goldfish in stroboscopic light: a quantitative WGA-HRP study.
1986,
Pubmed
Cook,
Interactions between optic fibres controlling the locations of their terminals in the goldfish optic tectum.
1979,
Pubmed
Cook,
A pattern of optic axons in the normal goldfish tectum consistent with the caudal migration of optic terminals during development.
1983,
Pubmed
Dubin,
A role for action-potential activity in the development of neuronal connections in the kitten retinogeniculate pathway.
1986,
Pubmed
Easter,
An evaluation of the hypothesis of shifting terminals in goldfish optic tectum.
1984,
Pubmed
Gaze,
Axial differences in the reinnervation of the goldfish optic tectum by regenerating optic nerve fibres.
1970,
Pubmed
Ginsburg,
Common noise in the firing of neighbouring ganglion cells in goldfish retina.
1984,
Pubmed
Harris,
The effects of eliminating impulse activity on the development of the retinotectal projection in salamanders.
1980,
Pubmed
Horder,
Some determinants of optic terminal localization and retinotopic polarity within fibre populations in the tectum of goldfish.
1982,
Pubmed
Johnsen,
Correlation of activity in neighbouring goldfish ganglion cells: relationship between latency and lag.
1983,
Pubmed
Keating,
Visual deprivation and the maturation of the retinotectal projection in Xenopus laevis.
1986,
Pubmed
,
Xenbase
Knudsen,
Experience alters the spatial tuning of auditory units in the optic tectum during a sensitive period in the barn owl.
1985,
Pubmed
Lewis,
Long-term potentiation in the goldfish optic tectum.
1986,
Pubmed
Mastronarde,
Correlated firing of cat retinal ganglion cells. I. Spontaneously active inputs to X- and Y-cells.
1983,
Pubmed
Meredith,
Spatial factors determine the activity of multisensory neurons in cat superior colliculus.
1986,
Pubmed
Meyer,
Tetrodotoxin inhibits the formation of refined retinotopography in goldfish.
1983,
Pubmed
Rankin,
Topographic refinement of the regenerating retinotectal projection of the goldfish in standard laboratory conditions: a quantitative WGA-HRP study.
1986,
Pubmed
Rodieck,
Maintained activity of cat retinal ganglion cells.
1967,
Pubmed
Sanes,
The sharpening of frequency tuning curves requires patterned activity during development in the mouse, Mus musculus.
1985,
Pubmed
Schmidt,
Stroboscopic illumination and dark rearing block the sharpening of the regenerated retinotectal map in goldfish.
1985,
Pubmed
Schmidt,
Formation of retinotopic connections: selective stabilization by an activity-dependent mechanism.
1985,
Pubmed
,
Xenbase
Schmidt,
Eye-specific segregation of optic afferents in mammals, fish, and frogs: the role of activity.
1985,
Pubmed
,
Xenbase
Schmidt,
Activity sharpens the map during the regeneration of the retinotectal projection in goldfish.
1983,
Pubmed
Stiles,
Periodic and nonperiodic burst responses of frog (Rana pipiens) retinal ganglion cells.
1985,
Pubmed
Udin,
The role of visual experience in the formation of binocular projections in frogs.
1985,
Pubmed
,
Xenbase
Whitelaw,
Specificity and plasticity of retinotectal connections: a computational model.
1981,
Pubmed
Willshaw,
How patterned neural connections can be set up by self-organization.
1976,
Pubmed
Wye-Dvorak,
Retinotectal reorganization in goldfish--I. Effects of season, lighting conditions and size of fish.
1979,
Pubmed
Yoon,
Effects of post-operative visual environments on reorganization of retinotectal projection in goldfish.
1975,
Pubmed
