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BMC Dev Biol 2008 Jun 23;8:92. doi: 10.1186/1471-213X-8-92.
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An ontology for Xenopus anatomy and development.

The frogs Xenopus laevis and Xenopus (Silurana) tropicalis are model systems that have produced a wealth of genetic, genomic, and developmental information. Xenbase is a model organism database that provides centralized access to this information, including gene function data from high-throughput screens and the scientific literature. A controlled, structured vocabulary for Xenopus anatomy and development is essential for organizing these data. We have constructed a Xenopus anatomical ontology that represents the lineage of tissues and the timing of their development. We have classified many anatomical features in a common framework that has been adopted by several model organism database communities. The ontology is available for download at the Open Biomedical Ontologies Foundry The Xenopus Anatomical Ontology will be used to annotate Xenopus gene expression patterns and mutant and morphant phenotypes. Its robust developmental map will enable powerful database searches and data analyses. We encourage community recommendations for updates and improvements to the ontology.

PubMed ID: 18817563
PMC ID: PMC2561031
Article link: BMC Dev Biol
Grant support: [+]

Species referenced: Xenopus laevis
Genes referenced: pax8

Article Images: [+] show captions
References [+] :
Altmann, Microarray-based analysis of early development in Xenopus laevis. 2001, Pubmed, Xenbase