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Dev Cell 2014 Nov 10;313:374-382. doi: 10.1016/j.devcel.2014.10.003.
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Sox5 Is a DNA-binding cofactor for BMP R-Smads that directs target specificity during patterning of the early ectoderm.

Nordin K , LaBonne C .

The SoxD factor, Sox5, is expressed in ectodermal cells at times and places where BMP signaling is active, including the cells of the animal hemisphere at blastula stages and the neural plate border and neural crest at neurula stages. Sox5 is required for proper ectoderm development, and deficient embryos display patterning defects characteristic of perturbations of BMP signaling, including loss of neural crest and epidermis and expansion of the neural plate. We show that Sox5 is essential for activation of BMP target genes in embryos and explants, that it physically interacts with BMP R-Smads, and that it is essential for recruitment of Smad1/4 to BMP regulatory elements. Our findings identify Sox5 as the long-sought DNA-binding partner for BMP R-Smads essential to plasticity and pattern in the early ectoderm.

PubMed ID: 25453832
PMC ID: PMC4255363
Article link: Dev Cell
Grant support: [+]

Species referenced: Xenopus
Genes referenced: babam2 bmp4 chrd foxd3 foxi1 foxi4 h3-3a id3 krt12.4 msx1 myc myod1 npb pax3 six1 smad1 smad10 smad2 smad3 smad4 smad7 snai2 sox10 sox15 sox3 sox5 sox6 sox8 sox9 tfap2a ventx1.2 ventx2.2 zic1
Antibodies: Myc Ab5 Myc Ab8 Smad1 Ab5 Smad1 Ab7 Smad2 Ab4
Morpholinos: sox5 MO2 sox5 MO3

Article Images: [+] show captions
References [+] :
Alliston, TGF-beta-induced repression of CBFA1 by Smad3 decreases cbfa1 and osteocalcin expression and inhibits osteoblast differentiation. 2001, Pubmed