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Summary Attributions
XB-LINE-1234

Line Name: Xtr.hps6mGrngr

Line Images

Summary
Synonym: No Privacy, NOP, noprivacy, T344-C, nop, Xtr.nopmGrngr
Species: Xenopus tropicalis
Background Strain: Xtr.Nigerian1EXRC
Paternal Line:
Maternal Line:
Description: No Privacy (NOP) embryos have a 10-bp deletion in the hps6 gene (a region from 468 to 477 counted from the beginning of the ORF). Mutation identified in the Grainger screen for ENU-induced mutations by gynogenesis. Positional cloning identified the site of mutation in the hps6 gene, which was confirmed by BAC rescue and targeted mutagenesis (by TALEN) of the hps6 gene. Model for Hermansky-Pudlak syndrome. Homozygous animals are viable, transparent. This colony was shared with the EXRC, the NXR, and the Khokha lab.
Phenotype Description: Markedly reduced pigmentation in the retina and the trunk from NF stage 39 onwards. Reduced production of pigmented melanophores by NF stage 50 and no production of pigmented iridophores. Albinos through to froglet stage, slight pigmentation as adults. Homozygous nop female crossed with with heterozygous males have abnormal inner ear morphology ( enlarged or absent inner ear otoliths, or absent otoliths and enlarged otic vesicle) .
Color Morph: pigmented
Breeding Type: INBRED
Lab of Origin: Grainger Lab
Line Type: Mutant
Mutated Gene(s): hps6
MTA Required: No
Public: Yes
Catalogue Number:

Stock Center RRID Generation Availability Mutant Details Information
NXR (US) NXR_10019
EXRC (Europe) EXRC_6003
NBRP (Japan)
XLRRI (US)

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