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Fig. 1. A single founder mutant embryo was raised to adulthood. (A) The founder mutant was photographed just as it was about to complete metamorphosis, which at this stage is indistinguishable from an albino froglet. (B) The founder mutant as an adult (a wildtype adult is shown in B for comparison). The white dotted square region is enlarged in the black dotted square (B) where one can recognize that the formation of melanin is partially restored. (C) Eggs, which are less pigmented than wildtype (C), were obtained from the adult in (B).
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Fig. 3. Appearance of visceral organs of no privacy and wildtype froglets. (A, B) Ventral view of outer surface of the peritoneum. (C, D) Ventral view of the liver (l), stomach (s), and intestine (i). (E, F) Dorsal view of the kidneys (k) and lungs (lu). (A, C, E) no privacy, (B, D, F) wildtype.
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Fig. 6. Maternal effect of nop mutation leads to otolith defect. Dorsal views, at stage 46, of nop (A) and wildtype (B) embryos derived from the heterozygous mutant parents and nop (C) and wildtype (D) embryos derived from the same heterozygous male as used for (A) and (B) and homozygous female. Only when the nop mutant is derived from a homozygous female are otolith defects seen (white arrows in white-dotted circles) as compared to normal otoliths (black arrows in black-dotted circles). Variation of otolith defects (indicated by white arrows) are seen in nop (EH) compared to the wildtype (I). (Br) Brain, (u) Utricle, (s) Saccule, (Ov) Otic vesicle.
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