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Line Name Species Mutated Gene(s) Description Availability
Xla.pkd1em3Horb X. laevis CRISPR knockout of pkd1 (polycystin 1, transient receptor potential channel interacting). Germ line ...
Xla.pkd1em2Horb X. laevis CRISPR knockout of pkd1 (polycystin 1, transient receptor potential channel interacting). Germ line ...
Xla.pkd1em1Horb X. laevis pkd1.L CRISPR knockout of pkd1 (polycystin 1, transient receptor potential channel interacting). Germ line...
Xla.pcntemHorb X. laevis pcnt.L CRISPR knockout of pcnt (pericentrin ). Confirmed germline transmission. Custom mutant generated by ...
Xla.pax7emHorb X. laevis pax7.L CRISPR knockout of pax7 (paired box ). Germ line transmission confirmed. Animals carry a 4bp 9 bp o...
Xla.pax3emHorb X. laevis pax3.L CRISPR knockout of pax3 (paired box 3). Germ line transmission confirmed. animals carry a 11bp delet...
Xla.olig3emHorb X. laevis olig3.S CRISPR knockout of olig3 (oligodendrocyte transcription factor 3) ( olig3.S in Xlaevis). Current mos...
Xla.olig2emHorb X. laevis olig2.L CRISPR knockout of olig2 (oligodendrocyte lineage transcription factor 2) in X. laevis. KOs both oli...
Xla.npffr1.1emEXRC X. laevis npffr1.1.L Crispr-Cas9 mutation in the npffr1.1 gene (neuropeptide FF receptor 1, gene 1 ).
Xla.notch4emHorb X. laevis notch4.S TALEN knockout of notch4 in X. laevis. THIS LINE is no longer available from the NXR
Xla.myogemNXR X. laevis myog.L CRISPR knockout of myog (myogenin) in Xlaevis. Germ line transmission not yet confirmed. F0 founders...
Xla.myod1emNXR X. laevis myod1.L CRISPR knockout of myod1 (myogenic differentiation 1) in X laevis. Germ line transmission not yet co...
Xla.myod1em2NXR X. laevis myod1.L CRISPR knockout of myod1 (myogenic differentiation 1) in X laevis. Germ line transmission not yet co...
Xla.myf6emNXR X. laevis myf6.L TALENS knockout of myf6 (myogenic factor 6) in X. laevis. Germ line transmission confirmed. Contact...
Xla.myf5emNXR X. laevis myf5.L CRISPR knockout of myf5 (myogenic factor 5). Germ line transmission not yet confirmed. F0 founders. ...
Xla.mitfemHorb X. laevis mitf.L CRISPR knockout of mitf (melanocyte inducing transcription factor) Germ line transmission confirmed....
Xla.mcidasemHorb X. laevis mcidas.L CRISPR knockout of mcidas (multiciliate differentiation and DNA synthesis associated cell cycle prot...
Xla.kcptmFlc X. laevis kcp.L One-cell stage Xenopus Xla.Tg(Cardiac-actin:GFP)Mohun embryos were microinjected with 1 ng TALEN mRN...
Xla.il2rgem2NXR X. laevis CRISPR knockout of il2rg (interleukin 2 receptor subunit gamma). Germ line transmission confirmed. A...
Xla.il2rgem1NXR X. laevis il2rg.L CRISPR knockout of il2rg (interleukin 2 receptor subunit gamma). Germ line transmission confirmed. ...
Xla.hps4m X. laevis hps4.L This periodic albino mutant of Xenopus laevis is a recessive mutant. Fukazawa et al 2020 showed that...
Xla.hmgcremHorb X. laevis hmgcr.L CRISPR knockout of hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase). Germline transmission confirmed...
Xla.gfi1emHorb X. laevis gfi1.L CRISPR knockout of gfi1 (growth factor independent 1 transcription repressor ).Confirmed germline tr...
Xla.fxr1emHorb X. laevis fxr1.L CRISPR Knockout of fxr1(FMR1 autosomal homolog 1 ). Currently mosaic founders. Confirmed germline tr...
Xla.foxn1em2NXR X. laevis CRISPR knockout of foxn1 (forkhead box N1). Germ line transmission confirmed, F1s established. Anima...
Xla.foxn1em1NXR X. laevis CRISPR knockout of foxn1 (forkhead box N1). Germ line transmission confirmed, F1s established. Anima...
Xla.eya1emHorb X. laevis eya1.L CRISPR Knockout of eya1 (EYA transcriptional coactivator and phosphatase 1) .gRNAs target eya1.L and...
Xla.dzip1emNXR X. laevis dzip1.L CRISPR knockout of dzip1 (Z interacting zinc finger protein 1). Germ line transmission not yet confi...
Xla.dmrt1em3NXR X. laevis dmrt1.S CRISPR knockout of dmrt1.S (doublesex and mab-3 related transcription factor 1 ). Custom mutant line...
Xla.dmrt1em2NXR X. laevis dmrt1.S CRISPR knockout of dmrt1.S (doublesex and mab-3 related transcription factor 1). Germline transmissi...
Xla.dmrt1em1NXR X. laevis dmrt1.L CRISPR knockout of dmrt1.L (doublesex and mab-3 related transcription factor 1 ). Germ line transmis...
Xla.cxcl8bemNXR X. laevis CRISPR knockout of cxcl8b (C-X-C motif chemokine ligand 8) and also known as il8b (interleukin-8). G...
Xla.cxcl8aemNXR X. laevis CRISPR knockout of cxcl8a (C-X-C motif chemokine ligand 8) and also known as il8a (interleukin-8). G...
Xla.csf3remNXR X. laevis csf3r.L CRISPR knockout of csf3r (colony stimulating factor 3 receptor ). Germ line transmission not yet con...
Xla.ccdc78emNXR X. laevis ccdc78.S CRISPR knockout of ccdc78 (coiled-coil domain containing 78). Germ line transmission confirmed. Muta...
Xla.baz1bemNXR X. laevis baz1b.L TALENs knockout of baz1b (bromodomain adjacent to zinc finger domain 1B ) aka wstf,a gene associated...
Xla.arem2NXR X. laevis ar.L CRISPR mutation of ar (androgen receptor). Mutation is confirmed as a 19bp deletion in ar.L (GAGTGTG...
Xla.arntlemNXR X. laevis bmal1.L CRISPR knockout of arntl (arbon receptor nuclear translocator like). Germline transmission confirme...
Xla.ar em1NXR X. laevis ar.L CRISPR mutation of ar (androgen receptor). Mutation is confirmed as a 13bp deletion in ar.L ( AGTGTG...
Xla.aqp1emHorb X. laevis aqp1.L CRISPR Knockout of aqp1.L and aqp1.S (Aquaporin1) Germline transmission confirmed. Mutation is a 1...
Xla.ahremNXR X. laevis ahr.L Custom generated mutant made by NXR. Germ line transmission not yet confirmed. Contact NXR for detai...
Xla.adam13emNXR X. laevis CRISPR knockout of adam13 (ADAM metallopeptidase domain 13 ). Confirmed germline transmission. Anima...
Xla.acsl5.LemNXR X. laevis CRISPR knock out of acsl5 (acyl-CoA synthetase long chain family member 5 ). F0 growing, Germ line t...

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