Search Lines and Strains
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| Line Name | Species | Mutated Gene(s) | Description | Availability |
| Xtr.gfi1em1Horb | X. tropicalis | gfi1 | CRISPR knockout of gfi1 (growth factor independent 1 transcription repressor). Germ line transmissio... | |
| Xtr.sox2emHorb | X. tropicalis | sox2 | CRISPR knockout of sox2 (SRY-box 2). Custom mutant line. Germ line transmission confirmed. Animals c... | |
| Xtr.otx2emHorb | X. tropicalis | otx2 | CRISPR knockout of otx2 (orthodenticle homeobox 2). Germ line transmission confirmed. Animals carry ... | |
| Xtr.kcnj11emHorb | X. tropicalis | kcnj8 | CRISPR knockout of kcnj11 (potassium channel, inwardly rectifying subfamily J, member 11). Germline ... | |
| Xtr.bcorem1Horb | X. tropicalis | bcor | CRISPR knockout of bcor (BCL6 corepressor). Germline transmission confirmed. Mutation is a 4bp delet... | |
| Xtr.nhlh1emHorb | X. tropicalis | nhlh1 | CRISPR knockout of nhlh1 (nescient helix-loop-helix 1). Germ line transmission confirmed. Mutation b... | |
| Xtr.wt1emHorb | X. tropicalis | wt1 | CRISPR knockout of wt1 (Wilms tumor 1). Germ line transmission confirmed. Animals carry a 5bp deleti... | |
| Xla.pkhd1emHorb | X. laevis | pkhd1.L | CRISPR knockout of pkhd1 (PKHD1, fibrocystin/polyductin), Germ line transmission confirmed. Animals ... | |
| Xla.pkd1em1Horb | X. laevis | pkd1.L | CRISPR knockout of pkd1 (polycystin 1, transient receptor potential channel interacting). Germ line... | |
| Xtr.foxb1em1Horb | X. tropicalis | foxb1 | CRISPR knockout of foxb1 (forkhead box B1 ), Current mosaic founders, germline transmission confirme... | |
| Xtr.dtlemHorb | X. tropicalis | dtl | CRISPR knockout of dtl (denticleless E3 ubiquitin protein ligase homolog), Current mosaic founders, ... | |
| Xtr.myt1emHorb | X. tropicalis | myt1 | CRISPR knockout of myt1 (myelin transcription factor 1). Germ line transmission confirmed. gRNA gene... | |
| Xtr.eomesemHorb | X. tropicalis | eomes | CRISPR knockout of eomes (eomesodermin). Germ line transmission confirmed. gRNA targets exon 1 and 2... | |
| Xtr.arnt,arnt2emHorb | X. tropicalis | arnt | CRISPR knockout of arnt/arnt2 (aryl hydrocarbon receptor nuclear translocator), Current mosaic found... | |
| Xtr.shroom3emHorb | X. tropicalis | shroom3 | CRISPR knockout of shroom3 (shroom family member 3), Current mosaic founders, Germ line transmissio... | |
| Xtr.zbtb21emHorb | X. tropicalis | zbtb21 | CRISPR knockout of zbtb21(zinc finger and BTB domain containing 21), Current mosaic founders, Not te... | |
| Xtr.tspan8em1Horb | X. tropicalis | tspan8 | CRISPR knockout of tspan8 (tetraspanin 8), Germ line transmission confirmed. 1of 3 tspan lines at th... | |
| Xtr.bace1emHorb | X. tropicalis | bace1 | CRISPR knockout of bace1 (beta-site APP-cleaving enzyme 1), Current mosaic founders, Not tested for ... | |
| Xtr.junbemHorb | X. tropicalis | junb | CRISPR knockout of junb (jun B proto-oncogene), Germ line transmission confirmed. Animals carry a 17... | |
| Xtr.mapk10emHorb | X. tropicalis | mapk10 | CRISPR knockout of mapk10 (mitogen-activated protein kinase 10), Germline transmission confirmed, Mu... | |
| Xtr.icam5emHorb | X. tropicalis | icam5 | CRISPR knockout of icam5 (intercellular adhesion molecule 5), Germ line transmission confirmed. Cust... | |
| Xtr.sox3emHorb | X. tropicalis | sox3 | CRISPR knockout of sox3 (SRY-box 3), Current mosaic founders, Not tested for germline transmission. ... | |
| Xtr.ezh2emHorb | X. tropicalis | ezh2 | CRISPR knockout of ezh2 (enhancer of zeste 2 polycomb repressive complex 2 subunit), Germ line trans... | |
| Xtr.tbx2emHorb | X. tropicalis | tbx2 | CRISPR knockout of tbx2 (T-box 2), Current mosaic founders, Not tested for germline transmission. | |
| Xtr.zbtb14emHorb | X. tropicalis | zbtb14 | CRISPR knockout of zbtb14 (zinc finger and BTB domain containing 14). Germ line transmission confirm... | |
| Xtr.notch4emHorb | X. tropicalis | notch4 | CRISPR knockout of notch4 in X. tropicalis. Confirmed germline transmission. Mutation characterized:... | |
| Xtr.tlx3em2Horb | X. tropicalis | tlx3 | CRISPR mutant line targeting tlx3 (T cell leukemia homeobox 3). Germ lIne transmission was confirmed... | |
| Xtr.runx1t1emHorb | X. tropicalis | runx1t1 | CRISPR knockout of runx1t1(RUNX1 partner transcriptional co-repressor 1) gene. Germ line transmissio... | |
| Xla.hmgcremHorb | X. laevis | hmgcr.L | CRISPR knockout of hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase). Germline transmission confirmed... | |
| Xtr.bhlhe22emHorb | X. tropicalis | bhlhe22 | CRISPR knockout of bhlhee2 (basic helix-loop-helix family member e22), Current mosaic founders, Conf... | |
| Xtr.kng1emHorb | X. tropicalis | kng1 | CRISPR knockout of kng1 (kininogen 1), Germline transmission confirmed. Mutants carry a bp deletion ... | |
| Xtr.fibinemHorb | X. tropicalis | fibin | CRISPR knockout of fibin (fin bud initiation factor homolog), Confirmed germline transmission. Custo... | |
| Xtr.tbx5emHorb | X. tropicalis | tbx5 | CRISPR knockout of tbx5 (T-box 5 ), Confirmed germline transmission. Custom mutant generated by Horb... | |
| Xtr.tyremNXR | X. tropicalis | tyr | CRISPR knockout of tyr (tyrosinase), Confirmed germline transmission. Animal carry a 241bp insertion... | |
| Xtr.raxmGrngr | X. tropicalis | rax | This mutant line was generated in an ENU screen from the Grainger lab by TILLING (Targeting Induced ... | |
| Xla.wnt11emHorb | X. laevis | wnt11.L | CRISPR knockout of wnt11 (Wnt family member 11), Confirmed germline transmission. Mutant line genera... | |
| Xla.wdpcpemHorb | X. laevis | wdpcp.L | CRISPR knockout of wdpcp (WD repeat containing planar cell polarity effector). Germ line transmissio... | |
| Xla.olig2emHorb | X. laevis | olig2.L | CRISPR knockout of olig2 (oligodendrocyte lineage transcription factor 2) in X. laevis. KOs both oli... | |
| Xla.notch4emHorb | X. laevis | notch4.S | TALEN knockout of notch4 in X. laevis. THIS LINE is no longer available from the NXR | |
| Xla.mcidasemHorb | X. laevis | mcidas.L | CRISPR knockout of mcidas (multiciliate differentiation and DNA synthesis associated cell cycle prot... | |
| Xla.sox10emHorb | X. laevis | sox10.L | CRISPR knockout of sox10 (SRY-box 10). Confirmed germline transmission in sox10.L (waiting for confi... | |
| Xla.slc16a2emHorb | X. laevis | slc16a2.L | CRISPR knockout of slc16a2 (solute carrier family 16, member 2 (thyroid hormone transporter)). Germ ... | |
| Xla.mitfemHorb | X. laevis | mitf.L | CRISPR knockout of mitf (melanocyte inducing transcription factor) Germ line transmission confirmed.... | |
| Xla.prph2emHorb | X. laevis | prph2.L | CRISPR knockout of prph2 (peripherin 2 (retinal degeneration, slow)). Current mosaic founders, not t... | |
| Xla.gfi1emHorb | X. laevis | gfi1.L | CRISPR knockout of gfi1 (growth factor independent 1 transcription repressor ).Confirmed germline tr... | |
| Xla.prickle1emHorb | X. laevis | prickle1.L | CRISPR knockout of prickle1(prickle planar cell polarity protein 1). Confirmed germ line transmissio... | |
| Xla.fxr1emHorb | X. laevis | fxr1.L | CRISPR Knockout of fxr1(FMR1 autosomal homolog 1 ). Currently mosaic founders. Confirmed germline tr... | |
| Xla.eya1emHorb | X. laevis | eya1.L | CRISPR Knockout of eya1 (EYA transcriptional coactivator and phosphatase 1) .gRNAs target eya1.L and... | |
| Xla.ppp2r2aemHorb | X. laevis | ppp2r2a.L | CRISPR knockout of ppp2r2a (protein phosphatase 2 regulatory subunit B, alpha ). Current mosaic foun... | |
| Xla.aqp1emHorb | X. laevis | aqp1.L | CRISPR Knockout of aqp1.L and aqp1.S (Aquaporin1) Germline transmission confirmed. Mutation is a 1... |
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