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Results 151 - 200 of 219 results

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Line Name Species Mutated Gene(s) Description Availability
Xtr.myt1emHorb X. tropicalis myt1 CRISPR knockout of myt1 (myelin transcription factor 1). Germ line transmission confirmed. gRNA gene...
Xtr.eomesemHorb X. tropicalis eomes CRISPR knockout of eomes (eomesodermin). Germ line transmission confirmed. gRNA targets exon 1 and 2...
Xtr.arnt,arnt2emHorb X. tropicalis arnt CRISPR knockout of arnt/arnt2 (aryl hydrocarbon receptor nuclear translocator), Current mosaic found...
Xtr.shroom3emHorb X. tropicalis shroom3 CRISPR knockout of shroom3 (shroom family member 3), Current mosaic founders, Germ line transmissio...
Xtr.zbtb21emHorb X. tropicalis zbtb21 CRISPR knockout of zbtb21(zinc finger and BTB domain containing 21), Current mosaic founders, Not te...
Xtr.tspan8em1Horb X. tropicalis tspan8 CRISPR knockout of tspan8 (tetraspanin 8), Germ line transmission confirmed. 1of 3 tspan lines at th...
Xtr.bace1emHorb X. tropicalis bace1 CRISPR knockout of bace1 (beta-site APP-cleaving enzyme 1), Current mosaic founders, Not tested for ...
Xtr.junbemHorb X. tropicalis junb CRISPR knockout of junb (jun B proto-oncogene), Germ line transmission confirmed. Animals carry a 17...
Xtr.mapk10emHorb X. tropicalis mapk10 CRISPR knockout of mapk10 (mitogen-activated protein kinase 10), Germline transmission confirmed, Mu...
Xtr.icam5emHorb X. tropicalis icam5 CRISPR knockout of icam5 (intercellular adhesion molecule 5), Germ line transmission confirmed. Cust...
Xtr.sox3emHorb X. tropicalis sox3 CRISPR knockout of sox3 (SRY-box 3), Current mosaic founders, Not tested for germline transmission. ...
Xtr.ezh2emHorb X. tropicalis ezh2 CRISPR knockout of ezh2 (enhancer of zeste 2 polycomb repressive complex 2 subunit), Germ line trans...
Xtr.tbx2emHorb X. tropicalis tbx2 CRISPR knockout of tbx2 (T-box 2), Current mosaic founders, Not tested for germline transmission.
Xtr.zbtb14emHorb X. tropicalis zbtb14 CRISPR knockout of zbtb14 (zinc finger and BTB domain containing 14). Germ line transmission confirm...
Xtr.notch4emHorb X. tropicalis notch4 CRISPR knockout of notch4 in X. tropicalis. Confirmed germline transmission. Mutation characterized:...
Xtr.tlx3em2Horb X. tropicalis tlx3 CRISPR mutant line targeting tlx3 (T cell leukemia homeobox 3). Germ lIne transmission was confirmed...
Xtr.runx1t1emHorb X. tropicalis runx1t1 CRISPR knockout of runx1t1(RUNX1 partner transcriptional co-repressor 1) gene. Germ line transmissio...
Xla.hmgcremHorb X. laevis hmgcr.L CRISPR knockout of hmgcr (3-hydroxy-3-methylglutaryl-CoA reductase). Germline transmission confirmed...
Xtr.bhlhe22emHorb X. tropicalis bhlhe22 CRISPR knockout of bhlhee2 (basic helix-loop-helix family member e22), Current mosaic founders, Conf...
Xtr.kng1emHorb X. tropicalis kng1 CRISPR knockout of kng1 (kininogen 1), Germline transmission confirmed. Mutants carry a bp deletion ...
Xtr.fibinemHorb X. tropicalis fibin CRISPR knockout of fibin (fin bud initiation factor homolog), Confirmed germline transmission. Custo...
Xtr.tbx5emHorb X. tropicalis tbx5 CRISPR knockout of tbx5 (T-box 5 ), Confirmed germline transmission. Custom mutant generated by Horb...
Xtr.tyremNXR X. tropicalis tyr CRISPR knockout of tyr (tyrosinase), Confirmed germline transmission. Animal carry a 241bp insertion...
Xtr.raxmGrngr X. tropicalis rax This mutant line was generated in an ENU screen from the Grainger lab by TILLING (Targeting Induced ...
Xla.wnt11emHorb X. laevis wnt11.L CRISPR knockout of wnt11 (Wnt family member 11), Confirmed germline transmission. Mutant line genera...
Xla.wdpcpemHorb X. laevis wdpcp.L CRISPR knockout of wdpcp (WD repeat containing planar cell polarity effector). Germ line transmissio...
Xla.olig2emHorb X. laevis olig2.L CRISPR knockout of olig2 (oligodendrocyte lineage transcription factor 2) in X. laevis. KOs both oli...
Xla.notch4emHorb X. laevis notch4.S TALEN knockout of notch4 in X. laevis. THIS LINE is no longer available from the NXR
Xla.mcidasemHorb X. laevis mcidas.L CRISPR knockout of mcidas (multiciliate differentiation and DNA synthesis associated cell cycle prot...
Xla.sox10emHorb X. laevis sox10.L CRISPR knockout of sox10 (SRY-box 10). Confirmed germline transmission in sox10.L (waiting for confi...
Xla.slc16a2emHorb X. laevis slc16a2.L CRISPR knockout of slc16a2 (solute carrier family 16, member 2 (thyroid hormone transporter)). Germ ...
Xla.mitfemHorb X. laevis mitf.L CRISPR knockout of mitf (melanocyte inducing transcription factor) Germ line transmission confirmed....
Xla.prph2emHorb X. laevis prph2.L CRISPR knockout of prph2 (peripherin 2 (retinal degeneration, slow)). Current mosaic founders, not t...
Xla.gfi1emHorb X. laevis gfi1.L CRISPR knockout of gfi1 (growth factor independent 1 transcription repressor ).Confirmed germline tr...
Xla.prickle1emHorb X. laevis prickle1.L CRISPR knockout of prickle1(prickle planar cell polarity protein 1). Confirmed germ line transmissio...
Xla.fxr1emHorb X. laevis fxr1.L CRISPR Knockout of fxr1(FMR1 autosomal homolog 1 ). Currently mosaic founders. Confirmed germline tr...
Xla.eya1emHorb X. laevis eya1.L CRISPR Knockout of eya1 (EYA transcriptional coactivator and phosphatase 1) .gRNAs target eya1.L and...
Xla.ppp2r2aemHorb X. laevis ppp2r2a.L CRISPR knockout of ppp2r2a (protein phosphatase 2 regulatory subunit B, alpha ). Current mosaic foun...
Xla.aqp1emHorb X. laevis aqp1.L CRISPR Knockout of aqp1.L and aqp1.S (Aquaporin1) Germline transmission confirmed. Mutation is a 1...
Xla.pkd2emHorb X. laevis pkd2.L CRISPR knockout of pkd2 (polycystin 2, transient receptor potential cation channel ). Confirmed germ...
Xla.pcntemHorb X. laevis pcnt.L CRISPR knockout of pcnt (pericentrin ). Confirmed germline transmission. Custom mutant generated by ...
Xla.pax7emHorb X. laevis pax7.L CRISPR knockout of pax7 (paired box ). Germ line transmission confirmed. Animals carry a 4bp 9 bp o...
Xla.pax3emHorb X. laevis pax3.L CRISPR knockout of pax3 (paired box 3). Germ line transmission confirmed. animals carry a 11bp delet...
Xla.olig3emHorb X. laevis olig3.S CRISPR knockout of olig3 (oligodendrocyte transcription factor 3) ( olig3.S in Xlaevis). Current mos...
Xla.slc45a1emNXR X. laevis slc45a1.L CRISPR knockout of Slc45a1 (solute carrier family 45 member 1 ). Screened for germline transmission....
Xtr.hpse2emHorb X. tropicalis hpse2 CRISPR knockout of hpse2 (heparanase 2 (inactive)). Confirmed germline transmission. Custom mutant g...
Xtr.glis3emHorb X. tropicalis glis3 CRISPR knockout of glis3 (GLIS family zinc finger 3). Confirmed germline transmission. Custom mutant...
Xtr.frzb,frzb2emHorb X. tropicalis frzb2 double CRISPR knockout of frzb (frizzled related protein ) and frzb2 (frizzled related protein 2). C...
Xtr.foxc2em1Horb X. tropicalis foxc2 CRISPR knockout of foxc2 (forkhead box C2). Confirmed germline transmission. Animals carry a 1 bp de...
Xtr.erfemHorb X. tropicalis erf CRISPR knockout of erf (ETS2 repressor factor). Confirmed germline transmission. Custom mutant gene...

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