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Xine Volume 10 - number 2, November 2010

Welcome to Xine, the source for Xenopus news and information. Here's
what's happening...

From Rob Grainger

Full-Time, Exempt

The Marine Biological Laboratory (MBL) in Woods Hole, Massachusetts is seeking a Director for the recently established NIH-NCRR-supported National Xenopus Resource.  The successful candidate will be expected to also conduct externally funded, independent research within one of the Centers or Programs of the MBL and will be considered for appointment at the Assistant, Associate or Senior Scientist level.

The successful candidate will directly oversee the scientific and operational needs of the Xenopus Resource Center, together with input and expertise contributed by an oversight board of Xenopus researchers from around the country.  The Center includes a newly renovated, purpose-built facility to support both Xenopus laevis and Xenopus tropicalis, a dedicated support staff, instrumentation and other support facilities, and other resources including a P40 support grant from the NIH's National Center for Research Resources (NCRR).  The overall goal of the National Xenopus Resource is to support basic and translational research using the Xenopus model, including maintenance of wild-type and mutant stocks; distribution to researchers within the national Xenopus community; generation of new transgenic lines; generation of animals for Xenopus genome resources; training of scientists in husbandry and other laboratory techniques for use of the model; hosting of laboratory courses, workshops and symposia for the Xenopus community; and promotion of Xenopus as a tool for modern biomedical research. The successful candidate is also encouraged, as an independent scientist, to take advantage of collaborative opportunities and synergies with the other research programs at the MBL, which include the recently established Eugene Bell Center for Regenerative Biology and Tissue Engineering, the Bay Paul Center for Comparative Molecular Biology and Evolution, the Cellular Dynamics Program, the Ecosystems Center, and the Marine Resources Center (see

Applicants must have a Doctorate in Biology or closely related field, extensive experience with Xenopus as a model research organism, strong managerial and supervisory experience, a strong record of scientific publication, and the potential to attract extramural funding to support their independent research.  The successful candidate will have the opportunity to establish a productive research program in a highly collaborative environment and may choose to join the faculty of the Brown University - MBL Partnership, which includes a joint graduate program.  In addition to its resident research program, the MBL hosts a visiting scientist program through its Whitman Center, advanced laboratory-based "discovery" courses through its educational program, and numerous workshops, symposia and other meetings through its conference program.  The MBL is part of a vibrant Woods Hole scientific community that includes the Woods Hole Oceanographic Institution, the Woods Hole Research Center, and several federal laboratories.

Applicants should submit CV, statement of interest in Directorship, separate statement of research interest, and list of four references on-line at:  <>.  Co-Chairs of the Xenopus Director Search Committee are Joshua Hamilton and Robert Grainger.

Advisory Committee: Robert Grainger, University of Virginia (Chair); Richard Harland, University of California, Berkeley; Mustafa Khokha, Yale University; Kristen Kroll, Washington University; John Wallingford, University of Texas, Austin.

The MBL is an Equal Opportunity/Affirmative Action Employer

From Frank Conlon

GPM (The Global Proteome Machine Organization Proteomics Database and Open Source Software),, of the Xenopus laevis and Xenopus tropicalis protein libraries are now available on their server. At long last, we have a decent data base to search for protein sequences.
News announcement is on:
From Matt Guille

European Xenopus Resource Centre - molecular resources.

In addition to the provision of wild-type, transgenic and mutant frogs
EXRC has started to collect, expand and test in situ hybridisation
probes and expression constructs from a number of labs. These can now be
supplied to researchers wanting them at cost (currently £8.50 + Post and
Packing). The list of available plasmids is currently on the centre
website (<>) but will also be
accessible via Xenbase shortly. If you wish to order or to deposit your
lab collection of plasmids please contact Xenopus
specific antibodies (£21 +P&P), the Xenopus tropicalis fosmids (£17.50
+P&P) and full-length, sequenced Xenopus laevis ESTs are also available,
details are again on the website. The centre is funded by the Wellcome
Trust and BBSRC.

Many thanks,

Call for content

Xine could be used to disseminate information and
protocols of general utility to the research community. In order for
this to occur, please send any such contributions to the editor who
will include them in a future (or special) issue of Xine.
If you wish to read Xine in html format and/or see back issues,
they are available at the following places
Links to useful sources of information for Xenopus (in no particular order)

general interest and utility
<> Trans NIH Xenopus
<> - Harland lab X. tropicalis site
<> - Grainger lab X. tropicalis site
<> - Amy Sater's X. tropicalis genetic map
<> - Information on the
X. tropicalis listserver
<> - Troplist archives.
Lots of good information here.
<> - Peter Vize's Xenopus über database
<> - Zimmerman Lab
X. tropicalis website, database of mutants
<> - Shoko Ishibashi's trop web page

genomic resources
<> - XDB at NIBB - Naoto Ueno's
X. laevis EST database <> - Xenopus gene collection
<> - full length
collection at the Gurdon Institute
<> - JGI X. tropicalis
genome site with browser and other info
AXELDB - Christof Niehrs' Xenopus database
Subscription information

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always, if you are not on the list and wish to be, want to update your
e-mail address or would rather not receive it at all, please contact
Bruce Blumberg (

Until next time,