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XB-PHENO-26022

Xla Wt + pax8 MO, Buisson I et al. (2015)

Experiment + Assay: Xla Wt + pax8 MO + NF33/34-35/36 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
morpholino injection pax8 MO3 pax8.L
pax8.S
 NF stage 4 (8-cell) blastomere
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 33 and 34 to NF stage 35 and 36  
Anatomical Phenotypes: abnormal pronephric kidney morphology , absent pronephric tubule
Expression Phenotypes (9):
absent cimap1a.L expression in pronephric nephrostome
absent mecom.L expression in distal tubule
absent mecom.L expression in early distal tubule
absent mecom.L expression in pronephric duct
absent pax2.L expression in pronephric duct
absent pax2.L expression in pronephric kidney
absent pax2.L expression in pronephric nephrostome
absent pax2.L expression in pronephric tubule
absent rgn.L expression in pronephric tubule
Source: Fig. 2. A a-d
Article: XB-ART-49971, PubMed