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XB-PHENO-24868

Xla Wt + rho CRISPR, Feehan JM et al. (2017)

Experiment + Assay: Xla Wt + rho CRISPR + NF49 (immunohistochemistry)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
CRISPR rho.2 gRNA1 rho.L
rho.S
rho.2.L
 NF stage 1 zygote
Conditions:
Assay Type Assay Stages Antibody
immunohistochemistry NF stage 49 Rho Ab3
Anatomical Phenotypes: abnormal photoreceptor layer morphology, abnormal retinal rod cell morphology, absent retinal rod cell
Expression Phenotypes (1):
decreased amount rho.L expression in photoreceptor layer
Human Disease Associations: retinitis pigmentosa
Source: Fig.1.B
Article: XB-ART-53879, PubMed