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XB-PHENO-23151

Xla Wt + Mmu.fgfr1del-Mmu.fkbp1adel + B/B Homodimerizer, Shifley ET et al. (2012)

Experiment + Assay: Xla Wt + Mmu.fgfr1del-Mmu.fkbp1adel + B/B Homodimerizer + NF35/36 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
mRNA injection Tg(Mmu.fgfr1del-Mmu.fkbp1adel) fgfr1.L
fgfr1.S
 NF stage 3 (4-cell) dorsal vegetal hemisphere blastomere
chemical B/B Homodimerizer
NF stage 18 whole organism
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 35 and 36  
Expression Phenotypes (7):
increased amount hhex.L expression in liver
increased amount nkx2-1.L expression in lung bud
increased amount nr1h5.L expression in liver
decreased amount pdx1.L expression in dorsal pancreatic bud
decreased amount pdx1.L expression in ventral pancreatic bud
decreased amount ptf1a.S expression in dorsal pancreatic bud
decreased amount ptf1a.S expression in ventral pancreatic bud
Source: fig.3.a,c
Article: XB-ART-45962, PubMed