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XB-PHENO-22939

Xla Wt + lhx1 MO + otx2 MO, Rankin SA et al. (2011)

Experiment + Assay: Xla Wt + lhx1 MO + otx2 MO + NF10.5 (in situ hybridization)
Background: Xla.Outbred
Manipulations:
Manipulation Type Reagent Target Gene Stage Treatment Area
morpholino injection otx2 MO1 otx2.L
otx2.S
 NF stage 2 (2-cell) blastomere
morpholino injection lhx1 MO1 lhx1.S
lhx1.L
 NF stage 2 (2-cell) blastomere
Conditions:
Assay Type Assay Stages Antibody
in situ hybridization NF stage 10.5  
Expression Phenotypes (5):
increased amount chrd.1.L expression in involuted dorsal mesoderm
decreased amount chrd.1.L expression in involuted dorsal mesoderm
mislocalised chrd.1.L expression in involuted dorsal mesoderm
decreased amount gsc.L expression in involuted dorsal mesoderm
decreased amount hhex.L expression in dorsal endomesoderm
Source: fig.S7
Article: XB-ART-42631, PubMed