Supl. Fig. 17 A

Kaiyrzhanov R et al. (2024)

Xtr Wt + acbd6 CRISPR (68)

NF10.5-11.5 gastrulation (whole-mount microscopy)

Anatomical Phenotype
abnormal gastrulation

Fig. 5 B (c3)

Kaiyrzhanov R et al. (2024)

Xtr Wt + acbd6 CRISPR (68)

NF28 (whole-mount microscopy)

Anatomical Phenotype
abnormal anterior-posterior axis, curved lateral abnormal gastrulation abnormal main body axis abnormally delayed closure of blastopore

Supl. Fig. 17 B

Kaiyrzhanov R et al. (2024)

Xtr Wt + acbd6 CRISPR (68)

NF42-43 (whole-mount microscopy)

Anatomical Phenotype
abnormal chondrocranium abnormal craniofacial region abnormal eye morphology abnormal pharyngeal region absent eye decreased size of the head

Fig. 5 G

Kaiyrzhanov R et al. (2024)

Xtr Wt + acbd6 CRISPR (68)

NF45 (3D imaging)

Anatomical Phenotype
abnormal brain morphology abnormal craniofacial region abnormal eye morphology abnormal jaw muscle abnormal midbrain morphology absent eye

microphthalmia

Fig. 5 H

Kaiyrzhanov R et al. (2024)

Xtr Wt + acbd6 CRISPR (68)

NF45 (behavioral assay)

Anatomical Phenotype
abnormal swimming behavior decreased swimming behavior

Fig. 5 EF

Kaiyrzhanov R et al. (2024)

Xtr Wt + acbd6 CRISPR (68)

NF45 (stained tissue microscopy)

Anatomical Phenotype
abnormal chondrocranium abnormal oropharynx abnormal pharyngeal region decreased size of the head

microcephaly

Fig. 5 CD

Kaiyrzhanov R et al. (2024)

Xtr Wt + acbd6 CRISPR (68)

NF45 (whole-mount microscopy)

Anatomical Phenotype
decreased size of the head

microcephaly

Supl. Fig 17 C

Kaiyrzhanov R et al. (2024)

Xtr Wt + acbd6 CRISPR (68)

NF46-47 (whole-mount microscopy)

Anatomical Phenotype
abnormal brain morphology abnormal chondrocranium abnormal craniofacial region abnormal eye morphology abnormal pharyngeal region absent eye decreased size of the head