nek2
has
5
expression phenotype(s)
Images
Sources
Experiment + Assay
Phenotypes
Human Diseases
Fig. 1 C
Endicott SJ et al. (2015)
Xtr Wt + Hsa.NEK2
NF16 (in situ hybridization)
Anatomical Phenotype
abnormal determination of left/right symmetry
Expression Phenotype
decreased amount
dand5
expression in left-right organizer
mislocalised
dand5
expression in left-right organizer
visceral heterotaxy
Fig. 1 B
Endicott SJ et al. (2015)
Xtr Wt + Hsa.NEK2
NF28 (in situ hybridization)
Anatomical Phenotype
abnormal determination of left/right symmetry in lateral plate mesoderm
Expression Phenotype
absent
pitx2
expression in lateral plate mesoderm
mislocalised
pitx2
expression in lateral plate mesoderm
visceral heterotaxy
Fig. 3 B D
Endicott SJ et al. (2015)
Xtr Wt + nek2 MO
NF16 (immunohistochemistry)
Expression Phenotype
decreased amount
tubg1
expression in left-right organizer
visceral heterotaxy
Fig. 1 C
Endicott SJ et al. (2015)
Xtr Wt + nek2 MO
NF16 (in situ hybridization)
Anatomical Phenotype
abnormal determination of left/right symmetry
Expression Phenotype
decreased amount
dand5
expression in left-right organizer
mislocalised
dand5
expression in left-right organizer
visceral heterotaxy
Fig. 1 B
Endicott SJ et al. (2015)
Xtr Wt + nek2 MO
NF28 (in situ hybridization)
Anatomical Phenotype
abnormal determination of left/right symmetry in lateral plate mesoderm
Expression Phenotype
absent
pitx2
expression in lateral plate mesoderm
mislocalised
pitx2
expression in lateral plate mesoderm
visceral heterotaxy
