Xtr Wt + nek2 MO has 7 phenotype(s)

Images

Sources

Experiment + Assay

Phenotypes

Human Diseases

Fig. 2 I

Endicott SJ et al. (2015)

Xtr Wt + nek2 MO

NF16 (immunohistochemistry)

Anatomical Phenotype
abnormally decreased number of cilium in the left-right organizer

visceral heterotaxy

Fig. 3 B D

Endicott SJ et al. (2015)

Xtr Wt + nek2 MO

NF16 (immunohistochemistry)

Expression Phenotype
decreased amount tubg1 expression in left-right organizer

visceral heterotaxy

Fig. 1 C

Endicott SJ et al. (2015)

Xtr Wt + nek2 MO

NF16 (in situ hybridization)

Anatomical Phenotype
abnormal determination of left/right symmetry

Expression Phenotype
decreased amount dand5 expression in left-right organizer mislocalised dand5 expression in left-right organizer

visceral heterotaxy

Fig. 2 B C G, Supp. Fig. S 1 D

Endicott SJ et al. (2015)

Xtr Wt + nek2 MO

NF16 (Other Detection Assay)

Anatomical Phenotype
abnormally decreased number of cilium in the left-right organizer

visceral heterotaxy

Fig. 1 B

Endicott SJ et al. (2015)

Xtr Wt + nek2 MO

NF28 (in situ hybridization)

Anatomical Phenotype
abnormal determination of left/right symmetry in lateral plate mesoderm

Expression Phenotype
absent pitx2 expression in lateral plate mesoderm mislocalised pitx2 expression in lateral plate mesoderm

visceral heterotaxy

Fig. 1 A

Endicott SJ et al. (2015)

Xtr Wt + nek2 MO

NF45 (whole-mount microscopy)

Anatomical Phenotype
abnormal heart looping

visceral heterotaxy

Fig. 4 K

Endicott SJ et al. (2015)

Xtr Wt + nek2 MO

NF45 (whole-mount microscopy)

Anatomical Phenotype
abnormal heart looping

visceral heterotaxy