isl1 has 10 expression phenotype(s)
Images Sources Experiment + Assay Phenotypes Human Diseases
No Image Fig. 8A

Flach H et al. (2022) 		Xla Wt + glyphosate [121.5]

NF20 (in situ hybridization)
Expression Phenotype
decreased amount isl1.L expression in cardiac progenitor cell
decreased amount nkx2-5.L expression in cardiac progenitor cell
No Image Fig.8BC

Flach H et al. (2022) 		Xla Wt + glyphosate [121.5]

NF28 (in situ hybridization)
Expression Phenotype
decreased amount isl1.L expression in heart primordium
decreased amount acta1.L expression in heart primordium
decreased amount myh6.L expression in heart primordium
decreased amount nkx2-5.L expression in heart primordium
No Image Fig. 8A

Flach H et al. (2022) 		Xla Wt + glyphosate [243]

NF20 (in situ hybridization)
Expression Phenotype
decreased amount isl1.L expression in cardiac progenitor cell
decreased amount nkx2-5.L expression in cardiac progenitor cell
No Image Fig. 8BC

Flach H et al. (2022) 		Xla Wt + glyphosate [243]

NF28 (in situ hybridization)
Expression Phenotype
decreased amount isl1.L expression in heart primordium
decreased amount acta1.L expression in heart primordium
decreased amount myh6.L expression in heart primordium
decreased amount nkx2-5.L expression in heart primordium
Fig, 5 B

Yang J et al. (2020) 		Xla Wt + xbp1 MO

NF37/38 (RT-PCR)
Expression Phenotype
decreased amount isl1.L expression in heart primordium
decreased amount neurog3.L expression in central nervous system
decreased amount pdx1.L expression in pancreas
decreased amount ptf1a.L expression in pancreas
decreased amount sox9.L expression in embryo
increased amount hhex.L expression in liver
Fig.3.S1.C

Mukherjee S et al. (2020) 		Xtr Wt + ctnnb1 MO

NF35/36 (in situ hybridization)
Anatomical Phenotype
wholly ventralized embryo
Expression Phenotype
absent isl1 expression in embryo
absent nr1h5 expression in embryo
absent osr1 expression in embryo
Fig.1.S1.C

Mukherjee S et al. (2020) 		Xtr Wt + sox17a MO + sox17b.1/b.2 MO

NF35/36 (in situ hybridization)
Expression Phenotype
decreased amount isl1 expression in eye
decreased amount isl1 expression in intestine
decreased amount isl1 expression in pharyngeal region
decreased amount isl1 expression in pharynx
decreased amount isl1 expression in profundus ganglion
decreased amount nr1h5 expression in liver
decreased amount nr1h5 expression in pharyngeal region
decreased amount osr1 expression in cement gland
decreased amount osr1 expression in intestine
decreased amount osr1 expression in lung
decreased amount osr1 expression in stomach
Fig. 6 J K L

Schwenty-Lara J et al. (2019) 		Xla Wt + kmt2d MO

NF29/30 (in situ hybridization)
Anatomical Phenotype
abnormal development of secondary heart field
Expression Phenotype
decreased amount isl1.L expression in secondary heart field
Kabuki syndrome
congenital heart disease
Fig.3.d

Chen YC et al. (2015) 		Xla Wt + prdm12 MO

NF28-28 (in situ hybridization)
Expression Phenotype
decreased amount isl1.S expression in neurogenic placode
decreased amount ebf3.L expression in neurogenic placode
decreased amount neurod4.L expression in neurogenic placode
Fig. 3 BD

Deimling SJ and Drysdale TA (2011) 		Xla Wt + su5402 (@12.5)

NF20 (in situ hybridization)
Expression Phenotype
decreased amount isl1.L expression in cardiac mesoderm
absent nkx2-5.L expression in cardiac mesoderm